TIMP3 抗体 (C-Term)
(2 references)Quick Overview for TIMP3 抗体 (C-Term) (ABIN3043694)
抗原
See all TIMP3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 198-211, C-Term
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原理
- Anti-Metalloproteinase inhibitor 3 TIMP3 Antibody Picoband®
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序列
- WAPPDKSIIN ATDP
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Metalloproteinase inhibitor 3 TIMP3 Antibody (ABIN3043694). Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human TIMP3, different from the related rat and mouse sequences by one amino acid.
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亚型
- IgG
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anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (Internal Region) antibody
TIMP3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 151-211) antibodyTIMP3 适用: 人, 大鼠, 兔 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 26-211) antibodyTIMP3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 113-139) antibodyTIMP3 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21049 unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 170-188) antibodyTIMP3 适用: 人, Cow, 犬, 马, Pig, 绵羊, 猴 WB, IHC, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 27-209) antibodyTIMP3 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 119-148), (Middle Region) antibodyTIMP3 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 176-210), (C-Term) antibodyTIMP3 适用: 人 WB 宿主: 兔 Polyclonal RB47669 unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 1-184) antibodyTIMP3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-TIMP Metallopeptidase Inhibitor 3 (TIMP3) (AA 30-208) antibodyTIMP3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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ELISA, 0.1-0.5 μg/mL, -
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)". 2. Apte, S. S., Mattei, M.-G., Olsen, B. R. : Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22. Genomics 19: 86-90, 1994. 3. Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (Apr 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med 9 (4): 407-15. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Promoter methylation and expression of TIMP3 gene in gastric cancer." in: Diagnostic pathology, Vol. 8, pp. 110, (2014) (PubMed).
: "Clinicopathologic significance of BAG1 and TIMP3 expression in colon carcinoma." in: World journal of gastroenterology, Vol. 13, Issue 28, pp. 3883-5, (2007) (PubMed).
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: "Promoter methylation and expression of TIMP3 gene in gastric cancer." in: Diagnostic pathology, Vol. 8, pp. 110, (2014) (PubMed).
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- TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))
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别名
- TIMP3
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背景
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Synonyms: Metalloproteinase inhibitor 3,Protein MIG-5,Tissue inhibitor of metalloproteinases 3,TIMP-3,TIMP3,
Background: Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene. It is mapped to 22q12.1-q13.2. This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of theextracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.
Sequence Similarities: Belongs to the protease inhibitor I35 (TIMP) family.
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分子量
- 91 kDa
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UniProt
- P35625
抗原
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