PER2 抗体 (AA 13-330)
Quick Overview for PER2 抗体 (AA 13-330) (ABIN3043602)
抗原
See all PER2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 13-330
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原理
- Anti-PER2 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-PER2 Antibody Picoband® (ABIN3043602). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human PER2 recombinant protein (Position: N13-K330). Human PER2 shares 84% and 83% amino acid (aa) sequence identity with mouse and rat PER2, respectively.
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亚型
- IgG
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anti-Period Circadian Protein 2 (PER2) (AA 1-100) antibody
PER2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 5C10 unconjugated
anti-Period Circadian Protein 2 (PER2) (AA 1-150) antibodyPER2 适用: 人 WB, IHC, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Period Circadian Protein 2 (PER2) (Middle Region) antibodyPER2 适用: 人, 小鼠, 大鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Period Circadian Protein 2 (PER2) (AA 751-850) antibodyPER2 适用: 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Period Circadian Protein 2 (PER2) antibodyPER2 适用: 人 WB, IF, ChIP 宿主: 兔 Monoclonal unconjugated
anti-Period Circadian Protein 2 (PER2) (pSer662) antibodyPER2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Period Circadian Protein 2 (PER2) (Internal Region) antibodyPER2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Period Circadian Protein 2 (PER2) (AA 923-1051) antibodyPER2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Period Circadian Protein 2 (PER2) antibodyPER2 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Period Circadian Protein 2 (PER2) (AA 1-100) antibodyPER2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Chen, R., Schirmer, A., Lee, Y., Lee, H., Kumar, V., Yoo, S.-H., Takahashi, J. S., Lee, C. Rhythmic PER abundance defines a critical nodal point for negative feedback within the circadian clock mechanism. Molec. Cell 36: 417-430, 2009. 2. Fu, L., Pelicano, H., Liu, J., Huang, P., Lee, C. C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 111: 41-50, 2002. Note: Erratum: 111: 1055 only, 2002. 3. Gery, S., Virk, R. K., Chumakov, K., Yu, A., Koeffler, H. P. The clock gene Per2 links the circadian system to the estrogen receptor. Oncogene 26: 7916-7920, 2007. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- PER2 (Period Circadian Protein 2 (PER2))
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别名
- PER2
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背景
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Synonyms: Period circadian protein homolog 2,hPER2,Circadian clock protein PERIOD 2,PER2,KIAA0347,
Tissue Specificity: Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level). .
Background: The PER2 gene encodes the period circadian protein homolog 2 protein in humans. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. PER2 is mapped to 2q37.3. It has been showed that PER2 can positively stimulate activity of the Bmal1-Npas2 transcription complex and, in turn, Npas2 transcriptionally regulates delta-aminolevulinate synthase. PER2 is involved in a negative-feedback loop that attenuates estrogen stimulation and links the circadian cycle to estrogen receptor signaling. The rhythmic levels of PER2 are critical for circadian oscillations in cells and intact organisms. What's more, the PER2 gene also functions in tumor suppression by regulating DNA damage-responsive pathways.
Sequence Similarities: Contains 1 PAC (PAS-associated C-terminal) domain.
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分子量
- 130 kDa
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基因ID
- 8864
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UniProt
- O15055
抗原
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