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PAX2A 抗体 (C-Term)

PAX2A 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3043591
发货至: 中国
  • 抗原 See all PAX2A 抗体
    PAX2A (Paired Box Gene 2a (PAX2A))
    抗原表位
    • 8
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 248-282, C-Term
    适用
    • 72
    • 36
    • 23
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 69
    • 7
    克隆类型
    • 61
    • 15
    多克隆
    标记
    • 39
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    This PAX2A antibody is un-conjugated
    应用范围
    • 48
    • 41
    • 18
    • 13
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    Anti-Pax2 Antibody Picoband®
    序列
    RKHLRADTFT QQQLEALDRV FERPSYPDVF QASEH
    交叉反应 (详细)
    No cross-reactivity with other proteins.
    产品特性
    Anti-Pax2 Antibody Picoband® (ABIN3043591). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence at the C-terminus of human Pax2, identical to the related mouse sequence.
    亚型
    IgG
    Top Product
    Discover our top product PAX2A Primary Antibody
  • 应用备注
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
    Western blot, 0.1-0.5 μg/mL, Rat, Human
    1. "Entrez Gene: PAX2 paired box gene 2". 2. Pilz AJ, Povey S, Gruss P, Abbott CM (1993). "Mapping of the human homologs of the murine paired-box-containing genes". Mamm. Genome 4 (2): 78-82. 3. Pfeffer, Peter L., Bernhard Payter, Gerlinde Reim, Marina Pasca di Magliano, Meinrad Busslinger (2001). "The activation and maintenance of Pax2 expression at the mid-hindbrain boundary is controlled by separate enhancers". Development (133): 307-318.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Yang, He, Peng, Zhong, Deng, Yu, Guan, Zuo, Xu: "Matrine suppresses the migration and invasion of NSCLC cells by inhibiting PAX2-induced epithelial-mesenchymal transition." in: OncoTargets and therapy, Vol. 10, pp. 5209-5217, (2017) (PubMed).

  • 抗原
    PAX2A (Paired Box Gene 2a (PAX2A))
    别名
    PAX2 (PAX2A 产品)
    背景

    Synonyms: Paired box protein Pax-2,PAX2,

    Tissue Specificity: Expressed in primitive cells of the kidney, ureter, eye, ear and central nervous system.

    Background: Paired box gene 2, also known as PAX2, is a protein which in humans is encoded by the PAX2 gene. This gene is mapped to 10q24. PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.

    分子量
    45 kDa
    基因ID
    5076
    UniProt
    Q02962
    途径
    Carbohydrate Homeostasis, Stem Cell Maintenance, Tube Formation
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