DLG4 抗体 (AA 581-724)
Quick Overview for DLG4 抗体 (AA 581-724) (ABIN3043563)
抗原
See all DLG4 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 581-724
-
原理
- Anti-PSD95/DLG4 Antibody Picoband®
-
交叉反应 （详细）
- No cross-reactivity with other proteins.
-
产品特性
- Anti-PSD95/DLG4 Antibody Picoband® (ABIN3043563). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- E.coli-derived human PSD95 recombinant protein (Position: H581-L724). Human PSD95 shares 100% amino acid (aa) sequence identity with both mouse and rat PSD95.
-
亚型
- IgG
-
-
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibody
DLG4 适用: 大鼠 WB, IHC, ICC, IF, AA, mIHC 宿主: 小鼠 Monoclonal 6G6 unconjugated
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) (C-Term) antibodyDLG4 适用: 大鼠, 人, 小鼠 WB, IHC, ELISA, IF, IP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibodyDLG4 适用: 大鼠 WB, IHC, ICC, IF, AA 宿主: 小鼠 Monoclonal 7E3 unconjugated
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibody (HRP)DLG4 适用: 大鼠 WB, IHC, ICC, IF, AA 宿主: 小鼠 Monoclonal 7E3 HRP
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibody (FITC)DLG4 适用: 大鼠 WB, IHC, ICC, IF, AA 宿主: 小鼠 Monoclonal 7E3 FITC
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibody (Biotin)DLG4 适用: 大鼠 WB, IHC, ICC, IF, AA 宿主: 小鼠 Monoclonal 7E3 Biotin
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibody (PE)DLG4 适用: 大鼠 WB, IHC, ICC, IF, AA 宿主: 小鼠 Monoclonal 7E3 PE
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibody (PerCP)DLG4 适用: 大鼠 WB, IHC, ICC, IF, AA 宿主: 小鼠 Monoclonal 7E3 PerCP
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibody (APC)DLG4 适用: 大鼠 WB, IHC, ICC, IF, AA 宿主: 小鼠 Monoclonal 7E3 APC
anti-Discs, Large Homolog 4 (Drosophila) (DLG4) antibody (Atto 488)DLG4 适用: 大鼠 WB, IHC, ICC, IF, AA 宿主: 小鼠 Monoclonal 7E3 Atto 488
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. "Entrez Gene: DLG4 discs, large homolog 4 (Drosophila)". 2. Colledge, M., Snyder, E. M., Crozier, R. A., Soderling, J. A., Jin, Y., Langeberg, L. K., Lu, H., Bear, M. F., Scott, J. D. Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression. Neuron 40: 595-607, 2003. 3. El-Husseini, A. E.-D., Schnell, E., Chetkovich, D. M., Nicoll, R. A., Bredt, D. S. PSD-95 involvement in maturation of excitatory synapses. Science 290: 1364-1368, 2000. -
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
-
-
- DLG4 (Discs, Large Homolog 4 (Drosophila) (DLG4))
-
别名
- DLG4
-
背景
-
Synonyms: Disks large homolog 4,Postsynaptic density protein 95,PSD-95,Synapse-associated protein 90,SAP-90,SAP90,DLG4,PSD95,
Tissue Specificity: Brain.
Background: DLG4 discs large homolog 4, also known as PSD95 or SAP-90, is a protein that in humans is encoded by the DLG4 gene. It is a member of the membrane-associated guanylate kinase (MAGUK) family. This gene is mapped to 17p13.1. DLG4 can heteromultimerize with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Overexpression of DLG4 in hippocampal neurons could drive maturation of glutamatergic synapses. DLG4 can orchestrate synaptic development and it has a role in synapse stabilization and plasticity. Ubiquitination of DLG4 through an MDM2-mediated pathway can regulate AMPA receptor surface expression during synaptic plasticity.
-
分子量
- 100 kDa
-
基因ID
- 1742
-
UniProt
- P78352
-
途径
- Regulation of Muscle Cell Differentiation, Synaptic Membrane, Skeletal Muscle Fiber Development, Asymmetric Protein Localization, Regulation of long-term Neuronal Synaptic Plasticity
抗原
-
