APOE 抗体 (AA 19-317)
Quick Overview for APOE 抗体 (AA 19-317) (ABIN3043523)
抗原
See all APOE 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-317
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原理
- Anti-Apolipoprotein E/APOE Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Apolipoprotein E/APOE Antibody Picoband® (ABIN3043523). Tested in ELISA, Flow Cytometry, IHC, IF, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Apolipoprotein E recombinant protein (Position: K19-H317). Human Apolipoprotein E shares 73% and 72% amino acid (aa) sequence identity with mouse and rat Apolipoprotein E, respectively.
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亚型
- IgG
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anti-Apolipoprotein E (APOE) (AA 19-181) antibody
APOE 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein E (APOE) (AA 19-168) antibodyAPOE 适用: 大鼠 WB, IHC, IP, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein E (APOE) (AA 1-172) antibodyAPOE 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein E (APOE) (AA 19-168) antibodyAPOE 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated
anti-Apolipoprotein E (APOE) (C-Term) antibodyAPOE 适用: 人 WB, ELISA, IP, ICC, IHC (p), IF, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein E (APOE) (AA 200-300) antibodyAPOE 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein E (APOE) antibodyAPOE 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1H4 unconjugated
anti-Apolipoprotein E (APOE) (N-Term) antibodyAPOE 适用: 人 WB, ICC, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein E (APOE) (AA 151-250) antibodyAPOE 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Apolipoprotein E (APOE) (AA 14-167) antibodyAPOE 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunofluorescence, 5 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
ELISA (Cap), 1-5 μg/mL1. Calabuig-Navarro MV, et al. Apolipoprotein E genotype has a modest impact on the postprandial plasma response to meals of varying fat composition in healthy men in a randomized controlled trial. J Nutr, 2014 Nov. 2. APOE ε variants increase risk of warfarin-related intracerebral hemorrhage.Falcone GJ, et al. Neurology, 2014 Sep 23. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- APOE (Apolipoprotein E (APOE))
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别名
- APOE
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背景
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Synonyms: Apolipoprotein E,Apo-E,APOE,
Tissue Specificity: Occurs in all lipoprotein fractions in plasma. It constitutes 10-20 % of very low density lipoproteins (VLDL) and 1-2 % of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.
Background: APOE is also known as AD2 or LPG. The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Alternative splicing results in multiple transcript variants.
Sequence Similarities: Belongs to the apolipoprotein A1/A4/E family.
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分子量
- 36 kDa
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基因ID
- 348
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UniProt
- P02649
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途径
- Regulation of Cell Size, Lipid Metabolism
抗原
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