CDC6 抗体 (AA 147-549)
Quick Overview for CDC6 抗体 (AA 147-549) (ABIN3043500)
抗原
See all CDC6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 147-549
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原理
- Anti-Cdc6 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Cdc6 Antibody Picoband® (ABIN3043500). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Cdc6 recombinant protein (Position: V147-A549). Human Cdc6 shares 87.3% amino acid (aa) sequence identity with mouse Cdc6.
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亚型
- IgG
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anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (AA 1-560) antibody
CDC6 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (AA 1-326) antibodyCDC6 适用: 人, 小鼠 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (AA 1-141) antibodyCDC6 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) antibodyCDC6 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (AA 434-533) antibodyCDC6 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (Internal Region) antibodyVerified CDC6 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (pSer54) antibodyCDC6 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB7524 unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (AA 20-69), (pSer54) antibodyCDC6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (N-Term), (pSer54) antibodyCDC6 适用: 人, 小鼠, 大鼠, 猴 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6) (pSer54) antibodyCDC6 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Gonzalez, S., Klatt, P., Delgado, S., Conde, E., Lopez-Rios, F., Sanchez-Cespedes, M., Mendez, J., Antequera, F., Serrano, M. Oncogenic activity of Cdc6 through repression of the INK4/ARF locus. Nature 440: 702-706, 2006. 2. Mimura, S., Seki, T., Tanaka, S., Diffley, J. F. X. Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 431: 1118-1123, 2004. 3. Whitmire, E., Khan, B., Coue, M. Cdc6 synthesis regulates replication competence in Xenopus oocytes. Nature 419: 722-725, 2002. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- CDC6 (Cell Division Cycle 6 Homolog (S. Cerevisiae) (CDC6))
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别名
- CDC6
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背景
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Synonyms: Cell division control protein 6 homolog,CDC6-related protein,Cdc18-related protein,HsCdc18,p62 (cdc6),HsCDC6,CDC6,CDC18L,
Tissue Specificity: Highly expressed in fetal lung, and kidney. In the adult, expression is mainly seen in lymphoid tissues, including spleen, thymus and peripheral blood lymphocytes.
Background: Cell division control ptotein 6 homolog, also called CDC18L or CDC6, is a protein that in humans is encoded by the CDC6 gene. By analysis of somatic cell hybrids and by fluorescence in situ hybridization, this gene is mapped to 17q21.2. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. And this protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. This gene is involved in the initiation of DNA replication.
Sequence Similarities: Belongs to the CDC6/cdc18 family.
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分子量
- 63 kDa
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基因ID
- 990
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UniProt
- Q99741
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途径
- DNA Replication, Synthesis of DNA
抗原
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