rala 抗体 (C-Term)
Quick Overview for rala 抗体 (C-Term) (ABIN3043449)
抗原
See all rala 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 165-203, C-Term
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原理
- Anti-RALA Antibody Picoband®
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序列
- DKVFFDLMRE IRARKMEDSK EKNGKKKRKS LAKRIRERC
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-RALA Antibody Picoband® (ABIN3043449). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human RALA, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Ras-related Protein Ral-A (rala) (AA 1-206) antibody
rala 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C13 unconjugated
anti-Ras-related Protein Ral-A (rala) (AA 71-203) antibodyrala 适用: 人, 小鼠, 猴 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 4G8C7 unconjugated
anti-Ras-related Protein Ral-A (rala) (AA 71-203) antibodyrala 适用: 人, 小鼠, 猴 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4G8B11 unconjugated
anti-Ras-related Protein Ral-A (rala) antibodyrala 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ras-related Protein Ral-A (rala) (Center) antibodyrala 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Ras-related Protein Ral-A (rala) (AA 1-203) antibodyrala 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ras-related Protein Ral-A (rala) (pSer194) antibodyrala 适用: 人 ELISA, IF, PLA 宿主: 小鼠 Monoclonal 3E6 unconjugated
anti-Ras-related Protein Ral-A (rala) (C-Term) antibodyrala 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ras-related Protein Ral-A (rala) (AA 1-206) antibodyrala 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ras-related Protein Ral-A (rala) (AA 1-206) antibodyrala 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: RALA v-ral simian leukemia viral oncogene homolog A (ras related)". 2. Kashatus DF (Sep 2013). "Ral GTPases in tumorigenesis: emerging from the shadows". Experimental Cell Research 319 (15): 2337-42. 3. Rousseau-Merck MF, Bernheim A, Chardin P, Miglierina R, Tavitian A, Berger R (Jun 1988). "The ras-related ral gene maps to chromosome 7p15-22". Human Genetics 79 (2): 132-6. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- rala (Ras-related Protein Ral-A (rala))
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别名
- RALA
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背景
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Synonyms: Ras-related protein Ral-A,RALA,RAL,
Tissue Specificity: Cells of the B- and T-lymphocyte lineages.
Background: Ras-related protein Ral-A (RalA) is a protein that in humans is encoded by the RALA gene on chromosome 7. This protein is one of two isoforms of the Ral protein, the other being RalB, and part of the Ras GTPase family. As a Ras GTPase, RalA functions as a molecular switch that becomes active when bound to GTP and inactive when bound to GDP. It can be activated by RalGEFs and, in turn, activate effectors in signal transduction pathways leading to biological outcomes. Additionally, Ral proteins have been associated with the progression of several cancers, including bladder cancer and prostate cancer. While the above functions appear to be shared between the two Ral isoforms, their differential subcellular localizations result in their differing involvement in certain biological processes. In particular, RalA is more involved in anchorage-independent cell growth, vesicle trafficking, and cytoskeletal organization. Moreover, RalA specifically interacts with Exo84 and Sec5 to regulate transport of membrane proteins in polarized epithelial cells and GLUT4 to the plasma membrane, as well as mitochondrial fission for cell division.
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分子量
- 24 kDa
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基因ID
- 5898
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UniProt
- P11233
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途径
- Neurotrophin Signaling Pathway, SARS-CoV-2 Protein Interactome
抗原
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