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TJP1 抗体 (AA 1178-1527)

This anti-TJP1 antibody is a 兔 多克隆 antibody detecting TJP1 in WB, IHC, IF, FACS 和 ICC. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN3043312
发货至: 中国

Quick Overview for TJP1 抗体 (AA 1178-1527) (ABIN3043312)

抗原

See all TJP1 抗体
TJP1 (Tight Junction Protein 1 (TJP1))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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多克隆

标记

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This TJP1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
  • 抗原表位

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    AA 1178-1527

    原理

    Anti-ZO1 tight junction protein/TJP1 Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-ZO1 tight junction protein/TJP1 Antibody Picoband® (ABIN3043312). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human TJP1 recombinant protein (Position: H1178-F1527). Human TJP1 shares 82% amino acid (aa) sequence identity with mouse TJP1.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Mohandas TK, Chen XN, Rowe LB, Birkenmeier EH, Fanning AS, Anderson JM, Korenberg JR (February 1997). "Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7". Genomics 30 (3): 594-7. 2. Willott, E., Balda, M. S., Fanning, A. S., Jameson, B., Van Itallie, C., Anderson, J. M. The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions. Proc. Nat. Acad. Sci. 90: 7834-7838, 1993.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Liu, Mei, Xu, Yu, Shi, Zhang, Wang, Zhang, Gao, Zhang, He: "Dual Receptor Recognizing Cell Penetrating Peptide for Selective Targeting, Efficient Intratumoral Diffusion and Synthesized Anti-Glioma Therapy." in: Theranostics, Vol. 6, Issue 2, pp. 177-91, (2017) (PubMed).

    Subramani, Ponnalagu, Krishna, Jeyabalan, Chevour, Sharma, Jayadev, Shetty, Begum, Archunan, Das: "Resveratrol reverses the adverse effects of bevacizumab on cultured ARPE-19 cells." in: Scientific reports, Vol. 7, Issue 1, pp. 12242, (2017) (PubMed).

    Lv, Phuong, Jin, Li, Xu: "Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes." in: Oncotarget, Vol. 8, Issue 53, pp. 91291-91305, (2017) (PubMed).

    Wen, Huang, Zhang, Zhang, Chen, Gu, Hao: "Resveratrol attenuates diabetic nephropathy via modulating angiogenesis." in: PLoS ONE, Vol. 8, Issue 12, pp. e82336, (2013) (PubMed).

  • 抗原

    TJP1 (Tight Junction Protein 1 (TJP1))

    别名

    TJP1

    背景

    Synonyms: Tight junction protein ZO-1,Tight junction protein 1,Zona occludens protein 1,Zonula occludens protein 1,TJP1,ZO1,

    Tissue Specificity: The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.

    Background: Tight junction protein ZO-1 is a protein that in humans is encoded by the TJP1 gene. It is mapped to 15q13.1. This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. It has been found that injected CagA associates with the epithelial tight-junction scaffolding protein TJP1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex.

    Sequence Similarities: Belongs to the MAGUK family.

    分子量

    220 kDa

    基因ID

    7082

    UniProt

    Q07157

    途径

    Carbohydrate Homeostasis, Cell-Cell Junction Organization
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