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Lipocalin 2 抗体 (AA 21-198)

This anti-Lipocalin 2 antibody is a 兔 多克隆 antibody detecting Lipocalin 2 in WB, ELISA, IHC 和 IHC (fro). Suitable for 人, 大鼠 和 小鼠. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN3043291
发货至: 中国

Quick Overview for Lipocalin 2 抗体 (AA 21-198) (ABIN3043291)

抗原

See all Lipocalin 2 (LCN2) 抗体
Lipocalin 2 (LCN2)

适用

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人, 大鼠, 小鼠

宿主

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克隆类型

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多克隆

标记

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This Lipocalin 2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

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    AA 21-198

    原理

    Anti-Lipocalin 2/LCN2 Antibody Picoband®

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-Lipocalin 2/LCN2 Antibody Picoband® (ABIN3043291). Tested in ELISA, IHC, IHC-F, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E. coli-derived rat Lipocalin 2 recombinant protein (Position: Q21-N198). Rat Lipocalin 2 shares 64.4 % and 81.1 % amino acid (aa) sequence identity with human and mouse Lipocalin 2, respectively.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Mouse
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Mouse, Rat
    ELISA (cap) ,1-5 μg/mL, Rat
    1. Cowland JB, Borregaard N (October 1997). "Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans". Genomics 45 (1): 17-23. 2. Chan P, Simon-Chazottes D, Mattei MG, Guenet JL, Salier JP (September 1994). "Comparative mapping of lipocalin genes in human and mouse: the four genes for complement C8 gamma chain, prostaglandin-D-synthase, oncogene-24p3, and progestagen-associated endometrial protein map to HSA9 and MMU2". Genomics 23 (1): 145-50. 3. Flo TH, Smith KD, Sato S, Rodriguez DJ, Holmes MA, Strong RK, Akira S, Aderem A (December 2004). "Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron". Nature 432 (7019): 917-21. 4. Kjeldsen L, Johnsen AH, Sengel111v H, Borregaard N (May 1993). "Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase". J. Biol. Chem. 268 (14): 10425-32. 5. Nelson AM, Zhao W, Gilliland KL, Zaenglein AL, Liu W, Thiboutot DM (April 2008). 6. Schmidt-Ott KM, Mori K, Li JY, Kalandadze A, Cohen DJ, Devarajan P, Barasch J (February 2007). "Dual action of neutrophil gelatinase-associated lipocalin". J. Am. Soc. Nephrol. 18 (2): 407-13.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Narayan, Duan, Jiang, Li, Paka, Yamin, Friedman, Weir, Goldberg: "Late intervention with the small molecule BB3 mitigates postischemic kidney injury." in: American journal of physiology. Renal physiology, Vol. 311, Issue 2, pp. F352-61, (2017) (PubMed).

    Li, Wang, He, Chen, Yu: "Expression of neutrophil gelatinase-associated lipocalin in low osmolar contrast-induced nephropathy in rats and the effect of N-acetylcysteine." in: Experimental and therapeutic medicine, Vol. 12, Issue 5, pp. 3175-3180, (2016) (PubMed).

  • 抗原

    Lipocalin 2 (LCN2)

    别名

    Lcn2

    背景

    Synonyms: Neutrophil gelatinase-associated lipocalin,NGAL,Alpha-2-microglobulin-related protein,Alpha-2U globulin-related protein,Lipocalin-2,Siderocalin LCN2,p25,Lcn2,

    Tissue Specificity: Detected in lung, spleen, uterus, vagina and epididymis. .

    Background: Europhile gelatinase-associated lipocalin (NGAL) is a protein that in humans is encoded by the LCN2 gene. The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor.

    Sequence Similarities: Belongs to the KIN17 family.

    分子量

    22 kDa

    基因ID

    170496

    UniProt

    P30152

    途径

    Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis
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