KIAA1524 抗体 (C-Term)
Quick Overview for KIAA1524 抗体 (C-Term) (ABIN3043277)
抗原
See all KIAA1524 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 854-889, C-Term
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原理
- Anti-p90 Autoantigen/KIAA1524 CIP2A Antibody Picoband®
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序列
- EVQKAQLEGR LEEKESLVKL QQEELNKHSH MIAMIH
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-p90 Autoantigen/KI CIP2A Antibody Picoband® (ABIN3043277). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human KIAA1524, different from the related mouse sequence by three amino acids.
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亚型
- IgG
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anti-KIAA1524 (KIAA1524) (AA 601-700) antibody
KIAA1524 适用: 人 WB, ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-KIAA1524 (KIAA1524) (AA 230-560) antibodyKIAA1524 适用: 人 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-KIAA1524 (KIAA1524) (AA 537-567) antibodyKIAA1524 适用: 人 WB 宿主: 兔 Polyclonal RB57595 unconjugated
anti-KIAA1524 (KIAA1524) antibodyKIAA1524 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-KIAA1524 (KIAA1524) (AA 269-301) antibodyKIAA1524 适用: 小鼠 WB 宿主: 兔 Polyclonal RB56267 unconjugated
anti-KIAA1524 (KIAA1524) (AA 681-905) antibodyKIAA1524 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse
1. Dong QZ, Wang Y, Dong XJ, Li ZX, Tang ZP, Cui QZ, Wang EH (September 2010). "CIP2A is Overexpressed in Non-Small Cell Lung Cancer and Correlates with Poor Prognosis". Ann Surg Oncol 18 (3): 857-865. 2. Junttila MR, Puustinen P, Niemelä M, et al. (2007). "CIP2A inhibits PP2A in human malignancies". Cell 130 (1): 51-62. 3. Khanna A, Böckelman C, Hemmes A, Junttila MR, Wiksten JP, Lundin M, Junnila S, Murphy DJ, Evan GI, Haglund C, Westermarck J, Ristimäki A (June 2009). "MYC-dependent regulation and prognostic role of CIP2A in gastric cancer". J. Natl. Cancer Inst. 101 (11): 793-805. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- KIAA1524
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别名
- CIP2A
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背景
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Synonyms: Protein CIP2A;Cancerous inhibitor of PP2A;p90 autoantigen;KIAA1524;CIP2A;
Tissue Specificity: Expressed at low levels in most of the tissues. Overexpressed in head-and-neck squamous cell carcinomas (HNSCC). Present in liver cancer cells (at protein level). .
Background: Protein CIP2A, also known as cancerous inhibitor of PP2A (CIP2A), is a protein that in humans is encoded by the KIAA1524 gene. CIP2A is required for the malignant cellular growth and for in vivo tumor formation. In accordance with the oncogenic role of CIP2A, overexpression of CIP2A promotes Ras-elicited cell growth and transforms immortalized human cells (HEK-TERVs). More recently CIP2A has been shown to regulate phosphorylation and activity of many other oncoproteins and to drive malignant cell growth and tumorigenesis in various human cancer types. Importantly, CIP2A deficient mice are viable, suggesting that targeting of oncogenic function of CIP2A would not result in serious side-effects.
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分子量
- 90 kDa
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基因ID
- 57650
抗原
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