Integrin Alpha2b 抗体 (C-Term)
Quick Overview for Integrin Alpha2b 抗体 (C-Term) (ABIN3043254)
抗原
See all Integrin Alpha2b (CD41) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 677-711, C-Term
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原理
- Anti-CD41/Integrin alpha 2b/ITGA2B Antibody Picoband®
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序列
- EAELAVHLPQ GAHYMRALSN VEGFERLICN QKKEN
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-CD41/Integrin alpha 2b/ITGA2B Antibody Picoband® (ABIN3043254). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human ITGA2B, different from the related mouse sequence by four amino acids.
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亚型
- IgG
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anti-Integrin Alpha2b (CD41) (AA 45-149) antibody
CD41 适用: 人 FACS, IHC, ELISA 宿主: 小鼠 Monoclonal 2E10C9 unconjugated
anti-Integrin Alpha2b (CD41) (AA 45-149) antibodyCD41 适用: 人 FACS, WB, IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated
anti-Integrin Alpha2b (CD41) (AA 351-450) antibodyCD41 适用: 人, 大鼠 FACS, WB, ELISA, IHC (fro), IHC (p), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Integrin Alpha2b (CD41) antibodyCD41 适用: 小鼠 FACS, ELISA, IP, IHC (fro), IHC (p), Func 宿主: 大鼠 Monoclonal MWReg30 unconjugated
anti-Integrin Alpha2b (CD41) antibodyCD41 适用: 小鼠 FACS, ELISA, IP, IHC (fro), IHC (p) 宿主: 大鼠 Monoclonal MWReg30 unconjugated
anti-Integrin Alpha2b (CD41) antibodyCD41 适用: 人, Non-Human Primate FACS, IHC (fro) 宿主: 小鼠 Monoclonal HIP2 unconjugated
anti-Integrin Alpha2b (CD41) antibody (Biotin)CD41 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-06 Biotin
anti-Integrin Alpha2b (CD41) antibody (FITC)CD41 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-06 FITC
anti-Integrin Alpha2b (CD41) (AA 639-887) antibodyCD41 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Integrin Alpha2b (CD41) (Internal Region) antibodyCD41 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
1. "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)". 2. Naik UP, Parise LV (1997). "Structure and function of platelet alpha IIb beta 3.". Curr. Opin. Hematol. 4(5): 317-22. 3. Quinn MJ, Byzova TV, Qin J et al. (2004). "Integrin alphaIIbbeta3 and its antagonism.". Arterioscler. Thromb. Vasc. Biol. 23 (6): 945-52. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Integrin Alpha2b (CD41)
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别名
- ITGA2B
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背景
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Synonyms: Integrin alpha-IIb,GPalpha IIb,GPIIb,Platelet membrane glycoprotein IIb,CD41,Integrin alpha-IIb heavy chain,Integrin alpha-IIb light chain, form 1,Integrin alpha-IIb light chain, form 2,ITGA2B,GP2B, ITGAB,
Tissue Specificity: Isoform 1 and isoform 2 were identified in platelets and megakaryocytes, but not in reticulocytes or in Jurkat and U-937 white blood cell line. Isoform 3 is expressed by leukemia, prostate adenocarcinoma and melanoma cells but not by platelets or normal prostate or breast epithelial cells.
Background: Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. It is mapped to 17q21.32. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
Sequence Similarities: Contains 1 HMG box DNA-binding domain.
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分子量
- 120-135 kDa
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基因ID
- 3674
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UniProt
- P08514
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途径
- Integrin Complex
抗原
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