PF4 抗体 (C-Term)
Quick Overview for PF4 抗体 (C-Term) (ABIN3043213)
抗原
See all PF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 85-101, C-Term
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原理
- Anti-Platelet factor 4 PF4 Antibody Picoband®
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序列
- DLQAPLYKKI IKKLLES
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Platelet factor 4 PF4 Antibody (ABIN3043213). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human PF4.
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亚型
- IgG
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anti-Platelet Factor 4 (PF4) (AA 31-101) antibody
PF4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Platelet Factor 4 (PF4) (AA 31-101) antibodyPF4 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C4 unconjugated
anti-Platelet Factor 4 (PF4) antibodyPF4 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Platelet Factor 4 (PF4) (AA 25-105) antibodyPF4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Platelet Factor 4 (PF4) (AA 31-101) antibodyPF4 适用: 人 WB, IP, ELISA 宿主: 小鼠 Monoclonal 3F6 unconjugated
anti-Platelet Factor 4 (PF4) (AA 1-101) antibodyPF4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Platelet Factor 4 (PF4) antibodyPF4 适用: 人 IHC, ELISA, IHC (p) 宿主: 绵羊 Polyclonal unconjugated
anti-Platelet Factor 4 (PF4) antibodyPF4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Platelet Factor 4 (PF4) (AA 30-105) antibodyPF4 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Platelet Factor 4 (PF4) (AA 30-105) antibodyPF4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Eisman, R., Surrey, S., Ramachandran, B., Schwartz, E., Poncz, M. Structural and functional comparison of the genes for human platelet factor 4 and PF4-alt. Blood 76: 336-344, 1990. 2. Griffin, C. A., Emanuel, B. S., LaRocco, P., Schwartz, E., Poncz, M. Human platelet factor 4 gene is mapped to 4q12-q21. Cytogenet. Cell Genet. 45: 67-69, 1987. 3. Lambert, M. P., Rauova, L., Bailey, M., Sola-Visner, M. C., Kowalska, M. A., Poncz, M. Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications. Blood 110: 1153-1160, 2007. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- PF4 (Platelet Factor 4 (PF4))
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别名
- PF4
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背景
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Synonyms: Platelet factor 4,PF-4,C-X-C motif chemokine 4,Iroplact,Oncostatin-A,Platelet factor 4, short form,PF4,CXCL4, SCYB4,
Tissue Specificity: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain.
Background: CXCL4, Chemokine (C-X-C motif) ligand 4, is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. CXCL4 belongs to the CXC chemokine family. The CXCL4 gene contains 3 exons spanning approximately 1 kb. The gene is encoded on a 10-kb EcoRI fragment of genomic DNA. By in situ hybridization, the CXCL4 gene is mapped to chromosome 4q12-q21. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair.
Sequence Similarities: Belongs to the intercrine alpha (chemokine CxC) family.
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分子量
- 50 kDa
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UniProt
- P02776
抗原
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