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Oncostatin M 抗体 (Middle Region)

Name: Oncostatin M 抗体 (Middle Region)
SKU: ABIN3043117
Availability: OutOfStock

OSM 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

Anti-Oncostatin M antibody, IHC(P) IHC(P):Human Intestinal Cancer Tissue (Oncostatin M 抗体 (Middle Region))

IHC

Western Blotting (WB) image for anti-Oncostatin M (OSM) (AA 181-198), (Middle Region) antibody (ABIN3043117) (Oncostatin M 抗体 (Middle Region))

2 images

(1 reference)

产品编号 ABIN3043117

发货至: 中国

Datasheet as PDF

抗原 See all Oncostatin M (OSM) 抗体

Oncostatin M (OSM)
抗原表位
14

6

6

5

3

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 181-198, Middle Region
适用
55

11

10
人
宿主
60

5

1

1

1

1
兔
Compatible Secondaries
克隆类型
62

7
多克隆
标记
35

8

5

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Oncostatin M antibody is un-conjugated
应用范围
50

28

12

12

8

6

5

4

3

3

3

2

2

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-Oncostatin M/OSM Antibody Picoband®

序列

ASDAFQRKLE GCRFLHGY

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Oncostatin M/OSM Antibody (ABIN3043117). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence in the middle region of human Oncostatin M.

亚型

IgG

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anti-Oncostatin M (OSM) antibody
OSM 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated

anti-Oncostatin M (OSM) (AA 26-220) antibody
OSM 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Oncostatin M (OSM) (AA 25-115) antibody
OSM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Oncostatin M (OSM) (AA 26-252) antibody
OSM 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Oncostatin M (OSM) (AA 26-220) antibody
OSM 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Oncostatin M (OSM) (AA 1-252) antibody
OSM 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Oncostatin M (OSM) (AA 1-252) antibody
OSM 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Oncostatin M (OSM) (AA 26-207) antibody
OSM 适用: 大鼠 ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Oncostatin M (OSM) (AA 1-252) antibody
OSM 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Miles, S. A., Martinez-Maza, O., Rezai, A., Magpantay, L., Kishimoto, T., Nakamura, S., Radka, S. F., Linsley, P. S. Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. Science 255: 1432-1434, 1992. 2. Modur, V., Feldhaus, M. J., Weyrich, A. S., Jicha, D. L., Prescott, S. M., Zimmerman, G. A., McIntyre, T. M. Oncostatin M is a proinflammatory mediator: in vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. J. Clin. Invest. 100: 158-168, 1997. 3. Rose, T. M., Bruce, A. G. Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. Proc. Nat. Acad. Sci. 88: 8641-8645, 1991.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
Zhu, Che, Liao, Wang, Wang, Chen, Wang, Dai, Wan: "Oncostatin M activates STAT3 to promote endometrial cancer invasion and angiogenesis." in: Oncology reports, Vol. 34, Issue 1, pp. 129-38, (2015) (PubMed).
抗原

Oncostatin M (OSM)

别名

OSM (OSM 产品)

背景

Synonyms: Oncostatin-M,OSM,OSM,
Tissue Specificity: Detected in neutrophils (at protein level). .
Background: OSM (ONCOSTATIN M) is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is mapped on 22q12.2. OSM has the ability to inhibit the growth of human A375 melanoma cells but not normal human fibroblasts. Treatment with recombinant OSM leads to the inhibition of proliferation and changes in cellular morphology of a number of tumor cell lines derived from a wide variety of tissue types. OSM also has the ability to inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells, a function shared by LIF, CSF3, and IL6. The ion of gene transcription was telomeric to centromeric, with the OSM gene located upstream of the LIF gene.
Sequence Similarities: Contains 1 FAD-binding FR-type domain.

分子量

28 kDa

UniProt

P13725

途径

JAK/STAT Signaling, Negative Regulation of Hormone Secretion