PFN2 抗体 (C-Term)
Quick Overview for PFN2 抗体 (C-Term) (ABIN3042861)
抗原
See all PFN2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 125-140, C-Term
-
原理
- Anti-Profilin 2/PFN2 Antibody Picoband®
-
序列
- NKKAYSMAKY LRDSGF
-
交叉反应 （详细）
- No cross-reactivity with other proteins
-
产品特性
- Anti-Profilin 2/PFN2 Antibody (ABIN3042861). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
-
纯化方法
- Immunogen affinity purified.
-
免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Profilin 2, identical to the related mouse and rat sequences.
-
亚型
- IgG
-
-
anti-Profilin 2 (PFN2) (AA 5-140) antibody
PFN2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Profilin 2 (PFN2) antibodyPFN2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Profilin 2 (PFN2) (C-Term) antibodyPFN2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Profilin 2 (PFN2) (AA 41-140) antibodyPFN2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6G3 unconjugated
anti-Profilin 2 (PFN2) (AA 51-140) antibodyPFN2 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Profilin 2 (PFN2) (AA 1-140) antibodyPFN2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Gieselmann, R., Kwiatkowski, D. J., Janmey, P. A., Witke, W. Distinct biochemical characteristics of the two human profilin isoforms. Europ. J. Biochem. 229: 621-628, 1995. 2. Joensuu, T., Blanco, G., Pakarinen, L., Sistonen, P., Kaariainen, H., Brown, S., de la Chapelle, A., Sankila, E.-M. Refined mapping of the Usher syndrome type III locus on chromosome 3, exclusion of candidate genes, and identification of the putative mouse homologous region. Genomics 38: 255-263, 1996. -
说明
-
Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
-
浓度
- 500 μg/mL
-
缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
-
储存液
- Thimerosal (Merthiolate), Sodium azide
-
注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- 4 °C,-20 °C
-
储存方法
-
Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
-
-
- PFN2 (Profilin 2 (PFN2))
-
别名
- PFN2
-
背景
-
Synonyms: Profilin-2,Profilin II,PFN2,
Tissue Specificity: Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver.
Background: Profilin-2, also called PFN2, is a protein that in humans is encoded by the PFN2 gene. The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. This gene is mapped to 3q25.1. It is though to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. It binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG.
Sequence Similarities: Contains 17 laminin EGF-like domains.
-
分子量
- 15 kDa
-
UniProt
- P35080
-
途径
- Regulation of Actin Filament Polymerization, Synaptic Vesicle Exocytosis
抗原
-
