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EGR2 抗体 (N-Term)

This anti-EGR2 antibody is a 兔 多克隆 antibody detecting EGR2 in WB. Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN3042850
发货至: 中国

Quick Overview for EGR2 抗体 (N-Term) (ABIN3042850)

抗原

See all EGR2 抗体
EGR2 (Early Growth Response 2 (EGR2))

适用

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人, 小鼠, 大鼠

宿主

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  • 1

克隆类型

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  • 16
多克隆

标记

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This EGR2 antibody is un-conjugated

应用范围

  • 54
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Western Blotting (WB)
  • 抗原表位

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    AA 153-168, N-Term

    原理

    Anti-EGR2 Antibody Picoband®

    序列

    TMSQTQPDLD HLYSPP

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-EGR2 Antibody (ABIN3042850). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    纯化方法

    Immunogen affinity purified.

    免疫原

    A synthetic peptide corresponding to a sequence at the N-terminus of human EGR2, different from the related rat and mouse sequences by one amino acid.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    1. Chung, K. W., Sunwoo, I. N., Kim, S. M., Park, K. D., Kim, W.-K., Kim, T. S., Koo, H., Cho, M., Lee, J., Choi, B. O. Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot-Marie-Tooth disease family. Neurogenetics 6: 159-163, 2005. 2. Szigeti, K., Wiszniewski, W., Saifi, G. M., Sherman, D. L., Sule, N., Adesina, A. M., Mancias, P., Papasozomenos, S. C., Miller, G., Keppen, L., Daentl, D., Brophy, P. J., Lupski, J. R. Functional, histopathologic and natural history study of neuropathy associated with EGR2 mutations. Neurogenetics 8: 257-262, 2007.

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    储存液

    Thimerosal (Merthiolate), Sodium azide

    注意事项

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    EGR2 (Early Growth Response 2 (EGR2))

    别名

    EGR2

    背景

    Synonyms: E3 SUMO-protein ligase EGR2,6.3.2.-,AT591,Early growth response protein 2,EGR-2,Zinc finger protein Krox-20,EGR2,KROX20,

    Tissue Specificity: In eosinophils as well as trace amounts in neutrophils and monocytes.

    Background: Early growth response protein 2, also called EGR2 or E3 SUMO-protein ligase EGR2, is a protein that in humans is encoded by the EGR2 gene. This gene is mapped to 10q21.3. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.

    Sequence Similarities: Belongs to the EGR C2H2-type zinc-finger protein family.

    分子量

    53 kDa

    UniProt

    P11161
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