EGR2 抗体 (N-Term)
Quick Overview for EGR2 抗体 (N-Term) (ABIN3042850)
抗原
See all EGR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 153-168, N-Term
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原理
- Anti-EGR2 Antibody Picoband®
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序列
- TMSQTQPDLD HLYSPP
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交叉反应 (详细)
- No cross-reactivity with other proteins
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产品特性
- Anti-EGR2 Antibody (ABIN3042850). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human EGR2, different from the related rat and mouse sequences by one amino acid.
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亚型
- IgG
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Chung, K. W., Sunwoo, I. N., Kim, S. M., Park, K. D., Kim, W.-K., Kim, T. S., Koo, H., Cho, M., Lee, J., Choi, B. O. Two missense mutations of EGR2 R359W and GJB1 V136A in a Charcot-Marie-Tooth disease family. Neurogenetics 6: 159-163, 2005. 2. Szigeti, K., Wiszniewski, W., Saifi, G. M., Sherman, D. L., Sule, N., Adesina, A. M., Mancias, P., Papasozomenos, S. C., Miller, G., Keppen, L., Daentl, D., Brophy, P. J., Lupski, J. R. Functional, histopathologic and natural history study of neuropathy associated with EGR2 mutations. Neurogenetics 8: 257-262, 2007. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Thimerosal (Merthiolate), Sodium azide
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- EGR2 (Early Growth Response 2 (EGR2))
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别名
- EGR2
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背景
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Synonyms: E3 SUMO-protein ligase EGR2,6.3.2.-,AT591,Early growth response protein 2,EGR-2,Zinc finger protein Krox-20,EGR2,KROX20,
Tissue Specificity: In eosinophils as well as trace amounts in neutrophils and monocytes.
Background: Early growth response protein 2, also called EGR2 or E3 SUMO-protein ligase EGR2, is a protein that in humans is encoded by the EGR2 gene. This gene is mapped to 10q21.3. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity.
Sequence Similarities: Belongs to the EGR C2H2-type zinc-finger protein family.
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分子量
- 53 kDa
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UniProt
- P11161
抗原
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