Leupaxin 抗体 (N-Term)
Quick Overview for Leupaxin 抗体 (N-Term) (ABIN3042842)
抗原
See all Leupaxin (LPXN) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 115-129, N-Term
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原理
- Anti-Leupaxin/LPXN Antibody Picoband®
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序列
- KKHLPDKQDH KASLD
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Leupaxin/LPXN Antibody (ABIN3042842). Tested in Flow Cytometry, WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human Leupaxin, different from the related rat sequence by two amino acids, and from the related mouse sequence by three amino acids.
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亚型
- IgG
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anti-Leupaxin (LPXN) (AA 1-300) antibody
LPXN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Leupaxin (LPXN) antibodyLPXN 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Leupaxin (LPXN) (AA 1-386) antibodyLPXN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Leupaxin (LPXN) (AA 1-208) antibodyLPXN 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Leupaxin (LPXN) (AA 229-257) antibodyLPXN 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB37022 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse
Flow Cytometry(Fixed), 1-3 μg/1x106 cells, Human
1. Lipsky, B. P., Beals, C. R., Staunton, D. E. Leupaxin is a novel LIM domain protein that forms a complex with PYK2. J. Biol. Chem. 273: 11709-11713, 1998. 2. "Entrez Gene: LPXN leupaxin". -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- Leupaxin (LPXN)
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别名
- LPXN
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背景
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Synonyms: Leupaxin,LPXN,LDLP,
Tissue Specificity: Macrophages, monocytes and osteoclasts (at protein level). Strongly expressed in cells and tissues of hematopoietic origin. Highest expression in lymphoid tissues such as spleen, lymph node, thymus and appendix and in the vascular smooth muscle. Lower levels in bone marrow and fetal liver. Also expressed in peripheral blood lymphocytes and a number of hematopoietic cell lines. Very low levels found in epithelial cell lines. Expressed in prostate cancer (PCa) cells and its expression intensity is ly linked to PCa progression. .
Background: Leupaxin is a protein that in humans is encoded by the LPXN gene. This gene is mapped to 11q12.1. The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity.
Sequence Similarities: Belongs to the paxillin family.
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分子量
- 43 kDa
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UniProt
- O60711
抗原
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