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COMT 抗体 (N-Term)

This anti-COMT antibody is a 兔多克隆 antibody detecting COMT in WB 和 IHC. Suitable for 人, 大鼠和小鼠.

Anti-COMT antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: A375 Cell Lysate Lane 3: PANC Cell Lysate (COMT 抗体 (N-Term))

Anti-COMT antibody, IHC(P) IHC(P): Human Lung Cancer Tissue (COMT 抗体 (N-Term))

Anti-COMT antibody, IHC(P) IHC(P): Human Kidney Cancer Tissue (COMT 抗体 (N-Term))

3 images

产品编号 ABIN3042837

发货至: 中国

Quick Overview for COMT 抗体 (N-Term) (ABIN3042837)

抗原

See all COMT 抗体

COMT (Catechol-O-Methyltransferase (COMT))

适用

58
39
39
5
3
3
2
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2
1
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人, 大鼠, 小鼠

宿主

兔

克隆类型

多克隆

标记

50
5
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1

This COMT antibody is un-conjugated

应用范围

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26
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13
8
8
3
3
3
1
1

Western Blotting (WB), Immunohistochemistry (IHC)

Discover our top product COMT Primary Antibody

抗原表位
15

7

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3

3

2

2

2

1

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1

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1
AA 94-108, N-Term

原理

Anti-Catechol O-methyltransferase COMT Antibody Picoband®

序列

DKKGKIVDAV IQEHQ

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-Catechol O-methyltransferase COMT Antibody (ABIN3042837). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human COMT.

亚型

IgG
anti-Catechol-O-Methyltransferase (COMT) (Internal Region) antibody
Verified COMT 适用: 人 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) antibody
KO Validated COMT 适用: 人 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (N-Term) antibody
Verified COMT 适用: 人 WB, ELISA, FACS 宿主: 山羊 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (AA 52-271) antibody
COMT 适用: 人, 大鼠, 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (AA 1-182) antibody
COMT 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G4-1A1 unconjugated

anti-Catechol-O-Methyltransferase (COMT) (AA 52-271) antibody
COMT 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (AA 1-221) antibody
COMT 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (AA 1-221) antibody
COMT 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (C-Term) antibody
COMT 适用: 人 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Catechol-O-Methyltransferase (COMT) (Internal Region) antibody
COMT 适用: 人, 大鼠, 小鼠, 猴, Cow, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
1. Baker, K., Baldeweg, T., Sivagnanasundaram, S., Scambler, P., Skuse, D. COMT val108/158met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome. Biol. Psychiat. 58: 23-31, 2005. 2. Lee, S.-G., Joo, Y., Kim, B., Chung, S., Kim, H.-L., Lee, I., Choi, B., Kim, C., Song, K.Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans. Hum. Genet. 116: 319-328, 2005.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Thimerosal (Merthiolate), Sodium azide

注意事项

This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

有效期

12 months
抗原

COMT (Catechol-O-Methyltransferase (COMT))

别名

COMT

背景

Synonyms: Catechol O-methyltransferase,2.1.1.6,COMT,
Tissue Specificity: Brain, liver, placenta, lymphocytes and erythrocytes.
Background: Catechol O-methyltransferase, also called COMT, is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines. This gene is mapped to 22q11.21. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini.
Sequence Similarities: Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O- methyltransferase family.

分子量

28 kDa

UniProt

P21964

途径

Steroid Hormone Biosynthesis, SARS-CoV-2 Protein Interactome

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