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CTGF 抗体 (AA 58-349)

Name: CTGF 抗体 (AA 58-349)
SKU: ABIN3042771
Availability: OutOfStock

CTGF 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

Western Blotting (WB) image for anti-Connective Tissue Growth Factor (CTGF) (AA 58-349) antibody (ABIN3042771) (CTGF 抗体 (AA 58-349))

Anti- CTGF Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue (CTGF 抗体 (AA 58-349))

IHC

2 images

(18 references)

产品编号 ABIN3042771

发货至: 中国

Datasheet as PDF

抗原 See all CTGF 抗体

CTGF (Connective Tissue Growth Factor (CTGF))
抗原表位
15

11

10

8

7

7

6

6

5

5

4

3

3

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1
AA 58-349
适用
114

57

50

7

4

3

2

2

1
人, 大鼠
宿主
120

41

3

2

1
兔
Compatible Secondaries
克隆类型
122

45
多克隆
标记
96

22

21

5

3

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CTGF antibody is un-conjugated
应用范围
136

93

67

52

45

20

17

14

12

12

5

3

3

3

2

2

1

1
Western Blotting (WB), Immunohistochemistry (IHC)

原理

Anti-CTGF Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-CTGF Antibody Picoband® (ABIN3042771). Tested in IHC, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

纯化方法

Immunogen affinity purified.

免疫原

E.coli-derived human CTGF recombinant protein (Position: R58-A349). Human CTGF shares 95.5% and 95.9% amino acid (aa) sequence identity with mouse and rat CTGF, respectively.

亚型

IgG

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CTGF 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal A7 unconjugated

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CTGF 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C2 unconjugated

anti-Connective Tissue Growth Factor (CTGF) (AA 253-349) antibody
CTGF 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Chen CC, Lau LF (April 2009). "Functions and mechanisms of action of CCN matricellular proteins". Int. J. Biochem. Cell Biol. 41 (4): 771-83. 2. Hall-Glenn F, Lyons KM (October 2011). "Roles for CCN2 in normal physiological processes". Cell. Mol. Life Sci. 68 (19): 3209-17. 3. Jun JI, Lau LF (December 2011). "Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets". Nat Rev Drug Discov 10 (12): 945-63.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Lu, Kang, Hu, Tang, Zhou, Yu, Xu: "Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis." in: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, Vol. 50, Issue 1, pp. e5594, (2017) (PubMed).

Lv, Wu, Li, Wang, Wang, Zhang, Xu, Zhang: "Effect of QiShenYiQi pill on myocardial collagen metabolism in experimental autoimmune myocarditis rats." in: Biomedicine & pharmacotherapy, Vol. 88, pp. 894-901, (2017) (PubMed).

Zhang, Li, Zheng, Lin, Zhang, Zhang: "Inhibition of angiogenesis by arsenic trioxide via TSP-1-TGF-β1-CTGF-VEGF functional module in rheumatoid arthritis." in: Oncotarget, Vol. 8, Issue 43, pp. 73529-73546, (2017) (PubMed).

Yang, Luo, Zhu, Zhou, Wang, Xue, Zhang, Cai, Chen, Ma, Chen, Wang, Luo, Liu, Zhao: "Chlorogenic Acid Inhibits Liver Fibrosis by Blocking the miR-21-Regulated TGF-β1/Smad7 Signaling Pathway in Vitro and in Vivo." in: Frontiers in pharmacology, Vol. 8, pp. 929, (2017) (PubMed).

Bai, Li, Zhao, Liu, Wang, Lian, Zhao, Wang: "PCPA protects against monocrotaline-induced pulmonary arterial remodeling in rats: potential roles of connective tissue growth factor." in: Oncotarget, Vol. 8, Issue 67, pp. 111642-111655, (2017) (PubMed).

Cheng, Xiao, Ainiwaer, Wang, Wu, Mao, Yang, Bao: "Molecular responses of radiation-induced liver damage in rats." in: Molecular medicine reports, Vol. 11, Issue 4, pp. 2592-600, (2015) (PubMed).

Ma, Li, Yue, Guo, Xu, Xu, Jia, Yu, Zhang, Liu, Liu, Shao, Chen, Liu: "Cryptotanshinone attenuates cardiac fibrosis via downregulation of COX-2, NOX-2, and NOX-4." in: Journal of cardiovascular pharmacology, Vol. 64, Issue 1, pp. 28-37, (2014) (PubMed).

Jin, Shi, Zou, Miao, Sun, Li: "Fenugreek Prevents the Development of STZ-Induced Diabetic Nephropathy in a Rat Model of Diabetes." in: Evidence-based complementary and alternative medicine : eCAM, Vol. 2014, pp. 259368, (2014) (PubMed).

Wang, Zhuang, Gao, Zhang, Yang: "Increased expression of CCN2 in the red flashing light-induced myopia in guinea pigs." in: BioMed research international, Vol. 2013, pp. 761823, (2014) (PubMed).

Guo, Qi, Yu, Du, Wu, Liu: "Effect of exenatide on the cardiac expression of adiponectin receptor 1 and NADPH oxidase subunits and heart function in streptozotocin-induced diabetic rats." in: Diabetology & metabolic syndrome, Vol. 6, Issue 1, pp. 29, (2014) (PubMed).

Li, Dai, Zhao, Zhang, Hui, Zhang, Jin: "Preventative effect of Astragalus flavescens on hepatic fibrosis in rats and its mechanism of action." in: Experimental and therapeutic medicine, Vol. 6, Issue 4, pp. 904-908, (2013) (PubMed).

Wang, Li, Lu, Zhao, Xu: "Taurine attenuates oxidative stress and alleviates cardiac failure in type I diabetic rats." in: Croatian medical journal, Vol. 54, Issue 2, pp. 171-9, (2013) (PubMed).

Wen, Huang, Zhang, Zhang, Chen, Gu, Hao: "Resveratrol attenuates diabetic nephropathy via modulating angiogenesis." in: PLoS ONE, Vol. 8, Issue 12, pp. e82336, (2013) (PubMed).

Li, Zhang, Wang, Zheng, Chen: "Nicousamide blocks the effects of advanced glycation end products on renal cells." in: European journal of pharmacology, Vol. 674, Issue 2-3, pp. 455-9, (2012) (PubMed).

Wang, Li, Lu, Zhao: "Riboflavin alleviates cardiac failure in Type I diabetic cardiomyopathy." in: Heart international, Vol. 6, Issue 2, pp. e21, (2012) (PubMed).

Wang, Hui, Fan, Xiong, Sun: "Filtering bleb area and intraocular pressure following subconjunctival injection of CTGF antibody after glaucoma filtration surgery in rabbits." in: International journal of ophthalmology, Vol. 4, Issue 5, pp. 480-3, (2012) (PubMed).

Wang, Li, Lu, Bao, Zhao: "Luteolin ameliorates cardiac failure in type I diabetic cardiomyopathy." in: Journal of diabetes and its complications, Vol. 26, Issue 4, pp. 259-65, (2012) (PubMed).

Guo, Zhang, Li, Xu: "Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats." in: Cardiovascular diabetology, Vol. 11, pp. 94, (2012) (PubMed).
抗原

CTGF (Connective Tissue Growth Factor (CTGF))

别名

CTGF (CTGF 产品)

背景

Synonyms: Connective tissue growth factor,CCN family member 2,Hypertrophic chondrocyte-specific protein 24,Insulin-like growth factor-binding protein 8,IBP-8,IGF-binding protein 8,IGFBP-8,CTGF,CCN2, HCS24, IGFBP8,
Tissue Specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. .
Background: CTGF, also known as CCN2 or connective tissue growth factor, is a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins (see also CCN intercellular signaling protein). CTGF has important roles in many biological processes, including cell adhesion, migration, proliferation, angiogenesis, skeletal development, and tissue wound repair, and is critically involved in fibrotic disease and several forms of cancers. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. And the encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis.
Sequence Similarities: Belongs to the CCN family.

分子量

38 kDa

基因ID

1490

UniProt

P29279

途径

Regulation of Lipid Metabolism by PPARalpha, Positive Regulation of Endopeptidase Activity, Growth Factor Binding