HSD17B6 抗体 (C-Term)
Quick Overview for HSD17B6 抗体 (C-Term) (ABIN3042725)
抗原
See all HSD17B6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 300-317, C-Term
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原理
- Anti-HSD17B6 Antibody Picoband®
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序列
- SLADYILTRS WPKPAQAV
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-HSD17B6 Antibody (ABIN3042725). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human HSD17B6.
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亚型
- IgG
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anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (AA 1-317) antibody
HSD17B6 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (N-Term) antibodyHSD17B6 适用: 人, 小鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (N-Term) antibodyHSD17B6 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) antibodyHSD17B6 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (N-Term) antibodyHSD17B6 适用: 人, 小鼠, 犬, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6) (AA 178-317) antibodyHSD17B6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Baker ME (Feb 2001). "Evolution of 17beta-hydroxysteroid dehydrogenases and their role in androgen, estrogen and retinoid action". Mol Cell Endocrinol 171 (1-2): 211-5. doi:10.1016/S0303-7207(00)00414-7. PMID 11165032. 2. Biswas, M. G., Russell, D. W. Expression cloning and characterization of oxidative 17-beta- and 3-alpha -hydroxysteroid dehydrogenases from rat and human prostate. J. Biol. Chem. 272: 15959-15966, 1997. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Sodium azide, Thimerosal (Merthiolate)
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注意事项
- This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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- HSD17B6 (Hydroxysteroid (17-Beta) Dehydrogenase 6 (HSD17B6))
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别名
- HSD17B6
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背景
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Synonyms: 17-beta-hydroxysteroid dehydrogenase type 6,17-beta-HSD 6,17-beta-HSD6,1.1.1.105,1.1.1.239,1.1.1.62,3-alpha->beta-hydroxysteroid epimerase,3-alpha->beta-HSE,Oxidative 3-alpha hydroxysteroid dehydrogenase,Short chain dehydrogenase/reductase family 9C member 6,HSD17B6,RODH, SDR9C6,
Tissue Specificity: Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. .
Background: Hydroxysteroid 17-beta dehydrogenase 6 is an enzyme that in humans is encoded by the HSD17B6 gene. The protein encoded by this gene has both oxidoreductase and epimerase activities and is involved in androgen catabolism. Baker ME et al point out expression of 17beta-HSDs had an important role in the early evolution of the physiological response to androgens and estrogens. Biswas and Russell concluded that 17beta-HSD6 and RoDH play opposing roles in androgen action, 17beta-HSD6 inactivates 3alpha-adiol by conversion to androsterone and RoDH activates 3alpha-adiol by conversion to dihydrotestosterone. The synthesis of an active steroid hormone by back conversion of an inactive metabolite represents a potentially important mechanism by which the steady state level of a transcriptional effector can be regulated.
Sequence Similarities: Belongs to the short-chain dehydrogenases/reductases (SDR) family.
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分子量
- 35 kDa
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UniProt
- O14756
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途径
- Steroid Hormone Biosynthesis
抗原
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