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P-Cadherin 抗体 (Middle Region)

CDH3 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042613
发货至: 中国
  • 抗原 See all P-Cadherin (CDH3) 抗体
    P-Cadherin (CDH3)
    抗原表位
    • 15
    • 9
    • 8
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 612-626, Middle Region
    适用
    • 97
    • 50
    • 7
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    宿主
    • 90
    • 17
    • 2
    • 2
    克隆类型
    • 90
    • 19
    • 1
    多克隆
    标记
    • 50
    • 11
    • 10
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This P-Cadherin antibody is un-conjugated
    应用范围
    • 92
    • 47
    • 40
    • 36
    • 23
    • 19
    • 14
    • 13
    • 12
    • 12
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    原理
    Anti-P-Cadherin-3 CDH3-Antibody Picoband®
    序列
    QDTYDVHLSL SDHGN
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-P-Cadherin-3 CDH3-Antibody (ABIN3042613). Tested in IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    A synthetic peptide corresponding to a sequence in the middle region of human P cadherin, different from the mouse and rat sequences by one amino acid.
    亚型
    IgG
    Top Product
    Discover our top product CDH3 Primary Antibody
  • 应用备注
    Immunocytochemistry , 0.5-1 μg/mL, Human, -
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (Dec 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics 14 (2): 488-90.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P) and ICC.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    储存液
    Thimerosal (Merthiolate), Sodium azide
    注意事项
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    P-Cadherin (CDH3)
    别名
    CDH3 (CDH3 产品)
    背景

    Synonyms: Cadherin-3,Placental cadherin,P-cadherin,CDH3,CDHP,

    Tissue Specificity: Expressed in some normal epithelial tissues and in some carcinoma cell lines. .

    Background: Cadherins, such as CDH3, are integral membrane glycoproteins responsible for calcium-dependent cell-cell adhesion. Cadherin-3 is a protein that in humans is encoded by the CDH3 gene. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.

    Sequence Similarities: Contains 5 cadherin domains.

    分子量
    120 kDa
    UniProt
    P22223
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