Progesterone Receptor 抗体 (AA 595-933)
(1 reference)Quick Overview for Progesterone Receptor 抗体 (AA 595-933) (ABIN3042523)
抗原
See all Progesterone Receptor (PGR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 595-933
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原理
- Anti-Progesterone Receptor/PGR Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Progesterone Receptor/PGR Antibody Picoband® (ABIN3042523). Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Progesterone Receptor recombinant protein (Position: M595-K933). Human Progesterone Receptor shares 95% and 94% amino acid (aa) sequences identity with mouse and rat Progesterone Receptor, respectively.
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亚型
- IgG
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anti-Progesterone Receptor (PGR) (AA 1-110) antibody
PGR 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 5D10 unconjugated
anti-Progesterone Receptor (PGR) (AA 166-411) antibodyPGR 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2E9F2 unconjugated
anti-Progesterone Receptor (PGR) (AA 166-411) antibodyPGR 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 2E4B9 unconjugated
anti-Progesterone Receptor (PGR) antibodyPGR 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 1-250) antibodyPGR 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 501-600) antibodyPGR 适用: 人 WB, ELISA, IHC (p), IF (p), IF (cc), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (pSer190) antibodyPGR 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (AA 483-571) antibodyPGR 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal PGR-2694 unconjugated
anti-Progesterone Receptor (PGR) (pSer400) antibodyPGR 适用: 人, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Progesterone Receptor (PGR) (pSer294) antibodyPGR 适用: 人, 大鼠, 小鼠, 猴 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
1. Misrahi M, Atger M, d'Auriol L, Loosfelt H, Meriel C, Fridlansky F, Guiochon-Mantel A, Galibert F, Milgrom E (March 1987). "Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA". Biochem. Biophys. Res. Commun. 143 (2): 740-8. 2. Law ML, Kao FT, Wei Q, Hartz JA, Greene GL, Zarucki-Schulz T, Conneely OM, Jones C, Puck TT, O'Malley BW (May 1987). "The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2". Proc. Natl. Acad. Sci. U.S.A. 84 (9): 2877-81. doi:10.1073/pnas.84.9.2877. PMC 304763. PMID 3472240. 3. Nishihara T, Kitaura M, Imagawa M, Nishikawa J (1995). "Vitamin D receptor contains multiple dimerization interfaces that are functionally different". Nucleic Acids Res. 23 (4): 606-611. 4. Schmitt J, De Vos P, Verhoeven G, Stunnenberg HG (1994). "Human androgen receptor expressed in HeLa cells activates transcription in vitro". Nucleic Acids Res. 22 (7): 1161-1166. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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: "Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure." in: Journal of ethnopharmacology, Vol. 139, Issue 1, pp. 26-33, (2011) (PubMed).
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: "Therapeutic mechanisms of Tongmai Dasheng Tablet on tripterygium glycosides induced rat model for premature ovarian failure." in: Journal of ethnopharmacology, Vol. 139, Issue 1, pp. 26-33, (2011) (PubMed).
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- Progesterone Receptor (PGR)
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别名
- PGR
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背景
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Synonyms: Progesterone receptor,PR,Nuclear receptor subfamily 3 group C member 3,PGR,NR3C3,
Tissue Specificity: Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine. .
Background: The progesterone receptor (PR) is an intracellular steroid receptor that specially binds progesterone in humans. PR has been a member of the steroid receptor superfamily. It is encoded by a single PGR gene residing on chromosome 11q22. The PGR gene uses separate promoters and translational start sites to produce 2 isoforms, PRA and PRB, which are identical except for an additional 165 amino acids present only in the N terminus of PRB. It can be observed in human breast tissues. The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner.
Sequence Similarities: Belongs to the nuclear hormone receptor family. NR3 subfamily.
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分子量
- 90 kDa (PR-A), 118 kDa (PR-B)
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UniProt
- P06401
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途径
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration
抗原
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