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PIN1 抗体 (AA 1-163)

PIN1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042501
发货至: 中国
  • 抗原 See all PIN1 抗体
    PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
    抗原表位
    • 15
    • 13
    • 10
    • 9
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    • 8
    • 6
    • 6
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    • 4
    • 4
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    • 2
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    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-163
    适用
    • 109
    • 51
    • 36
    • 8
    • 8
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 101
    • 13
    • 2
    • 1
    克隆类型
    • 103
    • 14
    多克隆
    标记
    • 58
    • 13
    • 12
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PIN1 antibody is un-conjugated
    应用范围
    • 86
    • 49
    • 39
    • 31
    • 20
    • 19
    • 14
    • 14
    • 13
    • 13
    • 5
    • 5
    • 3
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    • 1
    Western Blotting (WB)
    原理
    Rabbit IgG polyclonal antibody for Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(PIN1) detection. Tested with WB in Human,Mouse,Rat.
    交叉反应 (详细)
    No cross reactivity with other proteins.
    产品特性
    Rabbit IgG polyclonal antibody for Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1(PIN1) detection. Tested with WB in Human,Mouse,Rat.
    Gene Name: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
    Protein Name: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human Pin1 recombinant protein (Position: M1-E163). Human Pin1 shares 95% amino acid (aa) sequence identity with mouse Pin1.
    亚型
    IgG
    Top Product
    Discover our top product PIN1 Primary Antibody
  • 应用备注
    WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for Pin1 is approximately 0.1 ng/lane under reducing conditions.
    Notes: Tested Species: Species with positive results.
    Other applications have not been tested. Optimal dilutions should be determined by end users.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    At -20°C for one year. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
  • 抗原
    PIN1 (Peptidylprolyl Cis/trans Isomerase, NIMA-Interacting 1 (PIN1))
    别名
    PIN1 (PIN1 产品)
    别名
    DOD antibody, UBL5 antibody, dod antibody, ubl5 antibody, pin1 antibody, pin1a antibody, 0610025L01Rik antibody, D9Bwg1161e antibody, pin1b antibody, zgc:73206 antibody, PPIase pin1 antibody, MdPin1 antibody, Pin1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 S homeolog antibody, protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 antibody, peptidylprolyl cis/trans isomerase, NIMA-interacting 1 L homeolog antibody, peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody, peptidyl-prolyl cis-trans isomerase Pin1 antibody, PIN1 antibody, Pin1 antibody, pin1 antibody, pin1.S antibody, pin1.L antibody, ppiD antibody, PITG_11123 antibody, LOC103419188 antibody
    背景
    Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, also called DOD, is an enzyme that in humans is encoded by the PIN1 gene. It is mapped to 19p13.2. The enzyme binds to a subset of proteins and thus plays a role as a post phospho PIN1rol in regulating protein function. Studies have shown that the deregulation of PIN1 may play a pivotal role in various diseases. Notably, the up-regulation of PIN1 may be implicated in certain cancers, and the down-regulation of Pin1 may be implicated in Alzheimer's disease. Inhibitors of PIN1 may have therapeutic implications for cancer and immune disorders. PIN1 activity regulates the outcome of proline-directed kinase (e.g. MAPK, CDK or GSK3) signalling and consequently regulates cell proliferation (in part through control of cyclin D1 levels and stability) and cell survival. PIN1 also has an essential role in maintaining cell proliferation and regulating cyclin D1 function.

    Synonyms: DOD antibody|DODO, Drosophila, homolog of antibody|FLJ40239 antibody|FLJ77628 antibody|MGC10717 antibody|NIMA interacting 1 antibody|Peptidyl prolyl cis trans isomerase NIMA interacting 1 antibody|Peptidyl prolyl cis/trans isomerase NIMA interacting antibody|Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 antibody|Peptidyl-prolyl cis-trans isomerase pin1 antibody|Peptidylprolyl cis/trans isomerase NIMA interacting 1 antibody|Pin 1 antibody|Pin1 antibody|PIN1_HUMAN antibody|PPIase Pin1 antibody|Prolyl isomerase antibody|Protein (peptidylprolyl cis/trans isomerase) NIMA interacting 1 antibody|Protein NIMA interacting 1 antibody|Rotamase Pin1 antibody|UBL 5 antibody|UBL5 antibody
    基因ID
    5300
    UniProt
    Q13526
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