Otoferlin 抗体 (C-Term)
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Quick Overview for Otoferlin 抗体 (C-Term) (ABIN3042499)
抗原
See all Otoferlin (OTOF) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1831-1863, C-Term
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原理
- Anti-Otoferlin Antibody
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序列
- QIWDADHFSA DDFLGAIELD LNRFPRGAKT AKQ
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-Otoferlin Antibody (ABIN3042499). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminus of human Otoferlin, identical to the related mouse and rat sequences.
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亚型
- IgG
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anti-Otoferlin (OTOF) (AA 181-196) antibody
KO Validated OTOF 适用: 小鼠 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Mouse, Rat
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- Otoferlin (OTOF)
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别名
- OTOF
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背景
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Synonyms: Otoferlin,Fer-1-like protein 2,OTOF,FER1L2,
Tissue Specificity: Isoform 1 and isoform 3 are found in adult brain. Isoform 2 is expressed in the fetus and in adult brain, heart, placenta, skeletal muscle and kidney.
Background: Otoferlin is a protein that in humans is encoded by the OTOF gene. Mutations in this gene are a cause of neurosensory nonsyndromic recessive deafness, DFNB9. The short form of the encoded protein has three C2 domains, a single carboxy-terminal transmembrane domain found also in the C. elegans spermatogenesis factor FER-1 and human dysferlin, while the long form has six C2 domains. The homology suggests that this protein may be involved in vesicle membrane fusion. Several transcript variants encoding multipleisoforms have been found for this gene.
Sequence Similarities: Belongs to the ferlin family.
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分子量
- 227 kDa
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基因ID
- 9381
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途径
- Sensory Perception of Sound, Synaptic Vesicle Exocytosis
抗原
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