SMAD1 抗体 (Middle Region)
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北京 101111
Quick Overview for SMAD1 抗体 (Middle Region) (ABIN3042485)
抗原
See all SMAD1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Middle Region
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原理
- Anti-SMAD1 Antibody
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序列
- QPMDTNMMAP PLPSEINRGD VQAVAYEEPK H
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特异性
- No cross reactivity with other proteins.
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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预测反应
- different from the related mouse sequence by two amino acids,and from the related rat sequence by five amino acids.
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产品特性
- Anti-SMAD1 Antibody. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human SMAD1, different from the related mouse sequence by two amino acids, and from the related rat sequence by five amino acids.
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亚型
- IgG
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anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-465) antibody
SMAD1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2E9 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 20-240) antibodySMAD1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-465) antibodySMAD1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2A1 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-110) antibodySMAD1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1D3 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (pSer187) antibodySMAD1 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 202-335) antibodySMAD1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 20-330) antibodySMAD1 适用: 人 WB, IF, IHC (p) 宿主: 小鼠 Monoclonal 1356CT119-18-55 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 163-196) antibodySMAD1 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB43846 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (AA 1-465) antibodySMAD1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2A1 unconjugated
anti-SMAD, Mothers Against DPP Homolog 1 (SMAD1) (pSer465) antibodySMAD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
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说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles. -
有效期
- 12 months
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: "NLRC5 Mediates IL-6 and IL-1? Secretion in LX-2 Cells and Modulated by the NF-?B/Smad3 Pathway." in: Inflammation, Vol. 38, Issue 5, pp. 1794-804, (2015) (PubMed).
: "Quercetin prevents ethanol-induced iron overload by regulating hepcidin through the BMP6/SMAD4 signaling pathway." in: The Journal of nutritional biochemistry, Vol. 25, Issue 6, pp. 675-82, (2014) (PubMed).
: "Dexamethasone attenuates bleomycin-induced lung fibrosis in mice through TGF-?, Smad3 and JAK-STAT pathway." in: International journal of clinical and experimental medicine, Vol. 7, Issue 9, pp. 2645-50, (2014) (PubMed).
: "Effects of huogu I formula (I) on correlated factors of bone regeneration in chickens with steroid-induced necrosis of femoral head." in: Chinese journal of integrative medicine, Vol. 18, Issue 5, pp. 378-84, (2012) (PubMed).
: "Tranilast prevents the progression of chronic cyclosporine nephrotoxicity through regulation of transforming growth factor ?/Smad pathways." in: Transplantation proceedings, Vol. 43, Issue 5, pp. 1985-8, (2011) (PubMed).
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- SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))
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别名
- SMAD1
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背景
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Background: SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. It was concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-β superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.
Gene Full Name: SMAD family member 1
Sequence Similarities: Belongs to the dwarfin/SMAD family.
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分子量
- 52 kDa
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基因ID
- 4086
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UniProt
- Q15797
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途径
- Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
抗原
-
