IRF4 抗体 (AA 272-451)
Quick Overview for IRF4 抗体 (AA 272-451) (ABIN3042469)
抗原
See all IRF4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 272-451
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原理
- Anti-MUM1/IRF4 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-MUM1/IRF4 Antibody Picoband® (ABIN3042469). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human MUM1 recombinant protein (Position: E272-E451). Human MUM1 shares 92% amino acid (aa) sequence identity with mouse MUM1.
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亚型
- IgG
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anti-Interferon Regulatory Factor 4 (IRF4) (AA 342-451) antibody
IRF4 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (AA 342-451) antibodyIRF4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (AA 342-452) antibodyIRF4 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (AA 393-407) antibodyVerified IRF4 适用: 人, 大鼠 WB, ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (C-Term) antibodyIRF4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (N-Term) antibodyIRF4 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 马, Cow, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (AA 342-452) antibodyIRF4 适用: 人 WB, IHC (p), EIA 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (AA 175-433) antibodyIRF4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (AA 180-451) antibodyIRF4 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Interferon Regulatory Factor 4 (IRF4) (C-Term) antibodyVerified IRF4 适用: 人, 小鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Shaffer, A. L., Emre, N. C. T., Lamy, L., Ngo, V. N., Wright, G., Xiao, W., Powell, J., Dave, S., Yu, X., Zhao, H., Zeng, Y., Chen, B., Epstein, J., Staudt, L. M. IRF4 addiction in multiple myeloma. Nature 454: 226-231, 2008. 2. Grossman A, Mittrucker HW, Nicholl J, Suzuki A, Chung S, Antonio L, Suggs S, Sutherland GR, Siderovski DP, Mak TW (Feb 1997). "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25". Genomics 37 (2): 229-33. 3. Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665-76. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- IRF4 (Interferon Regulatory Factor 4 (IRF4))
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别名
- IRF4
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背景
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Synonyms: Interferon regulatory factor 4,IRF-4,Lymphocyte-specific interferon regulatory factor,LSIRF,Multiple myeloma oncogene 1,NF-EM5,IRF4,MUM1,
Tissue Specificity: Lymphoid cells.
Background: Interferon regulatory factor 4 (IRF4), also known as MUM1, is a protein that in humans is encoded by the IRF4 gene. It is located on 6p25.3. IRF4 is a transcription factor, and it is essential for the development of T helper-2 (Th2) cells, IL17 -producing Th17 cells, and IL9 -producing Th9 cells. In melanocytic cells, the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation, sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. What's more, IRF4 inhibition is toxic to myeloma cell lines, regardless of transforming oncogenic mechanism.
Sequence Similarities: Belongs to the IRF family.
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分子量
- 40 kDa
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基因ID
- 3662
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UniProt
- Q15306
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途径
- Chromatin Binding
抗原
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