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HSPG2 抗体 (AA 524-701)

HSPG2 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042466
发货至: 中国
  • 抗原 See all HSPG2 抗体
    HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))
    抗原表位
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 524-701
    适用
    • 23
    • 17
    • 6
    • 3
    • 3
    • 3
    • 3
    • 1
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    • 1
    宿主
    • 16
    • 5
    • 5
    克隆类型
    • 17
    • 9
    多克隆
    标记
    • 18
    • 2
    • 1
    • 1
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    • 1
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    • 1
    This HSPG2 antibody is un-conjugated
    应用范围
    • 14
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    • 6
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    • 5
    • 5
    • 3
    • 1
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    Western Blotting (WB), Immunohistochemistry (IHC)
    原理
    Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-Heparan Sulfate Proteoglycan 2/HSPG2 Antibody Picoband® (ABIN3042466). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human HSPG2 recombinant protein (Position: F524-K701). Human HSPG2 shares 86% amino acid (aa) sequence identity with mouse HSPG2.
    亚型
    IgG
    Top Product
    Discover our top product HSPG2 Primary Antibody
  • 应用备注
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Western blot, 0.1-0.5 μg/mL, Human
    1. Arikawa-Hirasawa E, Le AH, Nishino I, Nonaka I, Ho NC, Francomano CA et al. (May 2002). 2. Iozzo RV (1994). "Perlecan: a gem of a proteoglycan". Matrix Biol. 14 (3): 203-8. 3. Kallunki P, Eddy RL, Byers MG, Kestilä M, Shows TB, Tryggvason K (October 1991). "Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1----p35 and identification of a BamHI restriction fragment length polymorphism". Genomics 11 (2): 389-96.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原
    HSPG2 (Heparan Sulfate Proteoglycan 2 (HSPG2))
    别名
    HSPG2 (HSPG2 产品)
    背景

    Synonyms: Basement membrane-specific heparan sulfate proteoglycan core protein,HSPG,Perlecan,PLC,Endorepellin,LG3 peptide,HSPG2,

    Tissue Specificity: Found in the basement membranes.

    Background: Perlecan (PLC) also known as HSPG2, is a protein that in humans is encoded by the HSPG2 gene. It is mapped to 1p36.12. Perlecan is highly conserved across species and the available data indicate that it has evolved from ancient ancestors by gene duplication and exonshuffling. Perlecan is a key component of the vascular extracellular matrix, here it interacts with a variety of other matrix components and helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. Perlecan can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation.

    Sequence Similarities: Contains 4 EGF-like domains.

    分子量
    469 kDa
    基因ID
    3339
    UniProt
    P98160
    途径
    Glycosaminoglycan Metabolic Process, Lipid Metabolism
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