HSD17B10 抗体 (AA 48-261)
Quick Overview for HSD17B10 抗体 (AA 48-261) (ABIN3042460)
抗原
See all HSD17B10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 48-261
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原理
- Anti-ERAB/HSD17B10 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-ERAB/HSD17B10 Antibody Picoband® (ABIN3042460). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human ERAB recombinant protein (Position: E48-P261). Human ERAB shares 87% and 88% amino acid (aa) sequence identity with mouse and rat ERAB, respectively.
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亚型
- IgG
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anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) antibody
HSD17B10 适用: 人, 猴 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 5E2 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term) antibodyHSD17B10 适用: 人 WB, IF, IHC (p), ICC, IHC (wm) 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 48-261) antibodyHSD17B10 适用: 人, 小鼠 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 140-172) antibodyHSD17B10 适用: 人, 小鼠, 大鼠 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB56913 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) antibodyHSD17B10 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 1-261) antibodyHSD17B10 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 14-48) antibodyHSD17B10 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB56756 unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 1-261) antibodyHSD17B10 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (C-Term) antibodyVerified HSD17B10 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10) (AA 4-202) antibodyHSD17B10 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL
Immunocytochemistry/Immunofluorescence, 2 μg/mL
Flow Cytometry (Fixed), 1-3 μg/1x106 cells
1. Deutschmann AJ, et al. Mutation or knock-down of 17β-hydroxysteroid dehydrogenase type 10 cause loss of MRPP1 and impaired processing of mitochondrial heavy strand transcripts. Hum Mol Genet, 2014 Jul 1. 2. Yang SY, et al. Roles of 17β-hydroxysteroid dehydrogenase type 10 in neurodegenerative disorders. J Steroid Biochem Mol Biol, 2014 Sep. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- HSD17B10 (Hydroxysteroid (17-Beta) Dehydrogenase 10 (HSD17B10))
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别名
- HSD17B10
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背景
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Synonyms: 3-hydroxyacyl-CoA dehydrogenase type-2,1.1.1.35,17-beta-hydroxysteroid dehydrogenase 10,17-beta-HSD 10,1.1.1.51,3-hydroxy-2-methylbutyryl-CoA dehydrogenase,1.1.1.178,3-hydroxyacyl-CoA dehydrogenase type II,Endoplasmic reticulum-associated amyloid beta-peptide-binding protein,Mitochondrial ribonuclease P protein 2,Mitochondrial RNase P protein 2,Short chain dehydrogenase/reductase family 5C member 1,Short-chain type dehydrogenase/reductase XH98G2,Type II HADH,HSD17B10,ERAB, HADH2, MRPP2, SCHAD, SDR5C1, XH98G2,
Tissue Specificity: Ubiquitously expressed in normal tissues but is overexpressed in neurons affected in AD. .
Background: ERAB is also known as HSD17B10 or HADH2. This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.
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分子量
- 25 kDa
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基因ID
- 3028
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UniProt
- Q99714
抗原
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