电话:
+86 (0512) 65829739
传真:
+86 (010) 6788 5057
电子邮件:
orders@antibodies-online.cn

HNF1A 抗体 (AA 431-631)

HNF1A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042451
发货至: 中国
  • 抗原 See all HNF1A 抗体
    HNF1A (HNF1 Homeobox A (HNF1A))
    抗原表位
    • 15
    • 10
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 431-631
    适用
    • 55
    • 41
    • 26
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    宿主
    • 48
    • 6
    • 1
    克隆类型
    • 49
    • 6
    多克隆
    标记
    • 24
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HNF1A antibody is un-conjugated
    应用范围
    • 39
    • 14
    • 14
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    原理
    Anti-HNF1/HNF1A Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-HNF1/HNF1A Antibody Picoband® (ABIN3042451). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human HNF1 recombinant protein (Position: A431-Q631). Human HNF1 shares 93% and 92% amino acid (aa) sequences identity with mouse and rat HNF1, respectively.
    亚型
    IgG
    Top Product
    Discover our top product HNF1A Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Human
    1. Courtois, G., Morgan, J. G., Campbell, L. A., Fourel, G., Crabtree, G. R. Interaction of a liver-specific nuclear factor with the fibrinogen and alpha-1-antitrypsin promoters. Science 238: 688-692, 1987. 2. Szpirer C, Riviere M, Cortese R, Nakamura T, Islam MQ, Levan G, Szpirer J (June 1992). "Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF)". Genomics 13 (2): 293-300. 3. Vaxillaire M, Boccio V, Philippi A, Vigouroux C, Terwilliger J, Passa P, Beckmann JS, Velho G, Lathrop GM, Froguel P (April 1995). "A gene for maturity onset diabetes of the young (MODY) maps to chromosome 12q". Nat. Genet. 9 (4): 418-23.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Dai, Cai, Wu, Chen, Han: "Protocatechuic acid inhibits hepatitis B virus replication by activating ERK1/2 pathway and down-regulating HNF4α and HNF1α in vitro." in: Life sciences, Vol. 180, pp. 68-74, (2017) (PubMed).

  • 抗原
    HNF1A (HNF1 Homeobox A (HNF1A))
    别名
    HNF1A (HNF1A 产品)
    背景

    Synonyms: Hepatocyte nuclear factor 1-alpha,HNF-1-alpha,HNF-1A,Liver-specific transcription factor LF-B1,LFB1,Transcription factor 1,TCF-1,HNF1A,TCF1,

    Tissue Specificity: Liver.

    Background: HNF1 homeobox A (hepatocyte nuclear factor 1 homeobox A), also known as HNF1A or TCF1, is a human gene. It is mapped to chromosome 12q24.3. The protein encoded by this gene is a transcription factor that is highly expressed in the liver and is involved in the regulation of the expression of several liver-specific genes. HNF1A can function as a dimer. What's more, deletion of the HNF1A activation domains or interruption of the HNF1-binding sites in the LCT promoter resulted in complete loss of transcriptional activity.

    Sequence Similarities: Belongs to the HNF1 homeobox family.

    分子量
    80 kDa
    基因ID
    6927
    UniProt
    P20823
    途径
    Hormone Transport, Carbohydrate Homeostasis
You are here:
Chat with us!