HKDC1 抗体 (N-Term)
Quick Overview for HKDC1 抗体 (N-Term) (ABIN3042446)
抗原
See all HKDC1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 102-136, N-Term
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原理
- Anti-HKDC1 Antibody Picoband®
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序列
- KRHVQMESQF YPTPNEIIRG NGTELFEYVA DCLAD
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-HKDC1 Antibody Picoband® (ABIN3042446). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human HKDC1, different from the related mouse sequence by four amino acids.
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亚型
- IgG
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anti-Hexokinase Domain Containing 1 (HKDC1) (AA 129-427) antibody
HKDC1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hexokinase Domain Containing 1 (HKDC1) (AA 1-427) antibodyHKDC1 适用: 人 ELISA, IP 宿主: 小鼠 Monoclonal 3A2 unconjugated
anti-Hexokinase Domain Containing 1 (HKDC1) (AA 102-200) antibodyHKDC1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E8 unconjugated
anti-Hexokinase Domain Containing 1 (HKDC1) (AA 102-200) antibodyHKDC1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Hexokinase Domain Containing 1 (HKDC1) antibodyHKDC1 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Hexokinase Domain Containing 1 (HKDC1) (AA 1-427) antibodyHKDC1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Hexokinase Domain Containing 1 (HKDC1) (AA 150-250) antibodyHKDC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Herbst RS (2004). "Review of epidermal growth factor receptor biology". Int. J. Radiat. Oncol. Biol. Phys. 59 (2 Suppl): 21-6. 2. Wang, K., Yamamoto, H., Chin, J. R., Werb, Z., Vu, T. H.: Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. J. Biol. Chem. 279: 53848-53856, 2004. 3. Kuan CT, Wikstrand CJ, Bigner DD (June 2001). "EGF mutant receptor vIII as a molecular target in cancer therapy". Endocr. Relat. Cancer 8 (2): 83-96. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- HKDC1 (Hexokinase Domain Containing 1 (HKDC1))
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别名
- HKDC1
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背景
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Synonyms: Putative hexokinase HKDC1,2.7.1.1,Hexokinase domain-containing protein 1,HKDC1,
Tissue Specificity: Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.
Background: The epidermal growth factor receptor (HKDC1, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: HKDC1 (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). HKDC1 exists on the cell surface and is activated by binding of its specific ligands, including epidermal growth factor and transforming growth factor α (TGFα). HKDC1 and its ligands are cell signaling molecules involved in diverse cellular functions, including cell proliferation, differentiation, motility, and survival, and in tissue development. Mutations that lead to HKDC1 overexpression (known as upregulation) or overactivity have been associated with a number of cancers, including lung cancer and glioblastoma multiforme. In this latter case a more or less specific mutation of HKDC1, called HKDC1vIII is often observed.
Sequence Similarities: Belongs to the hexokinase family.
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分子量
- 103 kDa
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基因ID
- 80201
抗原
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