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- 抗原 See all HEXB 抗体
- HEXB (Hexosaminidase B (Beta Polypeptide) (HEXB))
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抗原表位
- AA 381-556
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HEXB antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC)
- 原理
- Anti-HEXB Antibody Picoband®
- 交叉反应 （详细）
- No cross-reactivity with other proteins
- 产品特性
- Anti-HEXB Antibody Picoband® (ABIN3042442). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
- 纯化方法
- Immunogen affinity purified.
- 免疫原
- E.coli-derived human HEXB recombinant protein (Position: K381-M556). Human HEXB shares 75% and 73% amino acid (aa) sequences identity with mouse and rat HEXB, respectively.
- 亚型
- IgG
- Top Product
- Discover our top product HEXB Primary Antibody
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anti-Hexosaminidase B (Beta Polypeptide) (HEXB) (AA 315-456) antibody
HEXB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) (AA 122-311) antibodyHEXB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) (AA 294-435) antibodyHEXB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) (AA 101-217) antibodyHEXB 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) (C-Term) antibodyHEXB 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) (C-Term) antibodyHEXB 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) antibodyMicroarray verified HEXB 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB461847 unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) antibodyMicroarray verified HEXB 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB220161 unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) (C-Term) antibodyHEXB 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Hexosaminidase B (Beta Polypeptide) (HEXB) (AA 408-528) antibodyHEXB 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. O'Dowd BF, Quan F, Willard HF, Lamhonwah AM, Korneluk RG, Lowden JA, Gravel RA, Mahuran DJ (Apr 1985). "Isolation of cDNA clones coding for the beta subunit of human beta-hexosaminidase". Proc Natl Acad Sci U S A 82 (4): 1184-8. 2. Korneluk RG, Mahuran DJ, Neote K, Klavins MH, O'Dowd BF, Tropak M, Willard HF, Anderson MJ, Lowden JA, Gravel RA (Jul 1986). "Isolation of cDNA clones coding for the alpha-subunit of human beta-hexosaminidase. Extensive homology between the alpha- and beta-subunits and studies on Tay-Sachs disease". J Biol Chem 261 (18): 8407-13. 3. "Entrez Gene: HEXB hexosaminidase B (beta polypeptide)" - 说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- 浓度
- 500 μg/mL
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C,-20 °C
- 储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- 抗原
- HEXB (Hexosaminidase B (Beta Polypeptide) (HEXB))
- 别名
- HEXB (HEXB 产品)
- 背景
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Synonyms: Beta-hexosaminidase subunit beta,3.2.1.52,Beta-N-acetylhexosaminidase subunit beta,Hexosaminidase subunit B,Cervical cancer proto-oncogene 7 protein,HCC-7,N-acetyl-beta-glucosaminidase subunit beta,Beta-hexosaminidase subunit beta chain B,Beta-hexosaminidase subunit beta chain A,HEXB,HCC7,
Tissue Specificity: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. .
Background: Beta-hexosaminidase subunit beta (HEXB) is an enzyme that in humans is encoded by the HEXB gene. It is mapped to 5q13.3. HEXB is the beta subunit of the lysosomal enzyme beta-hexosaminidase that, together with the cofactor GM2 activator protein, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Beta subunit gene mutations lead to Sandhoff disease (GM2-gangliosidosis type II). It has been found that HEXB is a peptidoglycan hydrolase and it is involved in restricting mycobacteria growth even before the onset of adaptive immunity.
Sequence Similarities: Belongs to the glycosyl hydrolase 20 family.
- 分子量
- 63 kDa
- 基因ID
- 3074
- UniProt
- P07686
- 途径
- Sensory Perception of Sound, Glycosaminoglycan Metabolic Process
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