HCN1 抗体 (AA 618-890)
Quick Overview for HCN1 抗体 (AA 618-890) (ABIN3042439)
抗原
See all HCN1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 618-890
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原理
- Anti-HCN1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-HCN1 Antibody Picoband® (ABIN3042439). Tested in WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human HCN1 recombinant protein (Position: E618-L890). Human HCN1 shares 82% amino acid (aa) sequence identity with both mouse and rat HCN1.
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亚型
- IgG
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anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody
HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 unconjugated
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (HRP)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 HRP
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (FITC)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 FITC
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (Biotin)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 Biotin
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (PE)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 PE
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (PerCP)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 PerCP
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (APC)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 APC
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (Atto 488)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 Atto 488
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (Atto 594)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 Atto 594
anti-Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1) (AA 778-910) antibody (Atto 390)HCN1 适用: 大鼠 WB, IHC, IP, AA 宿主: 小鼠 Monoclonal S70 Atto 390
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
1. Santoro B, Grant SG, Bartsch D, Kandel ER (Feb 1998). "Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels". Proc Natl Acad Sci U S A 94 (26): 14815-20. 2. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (Jul 1998). "Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain". Cell 93 (5): 717-29. 3. Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev 57 (4): 455-62. 4. "Entrez Gene: HCN1 hyperpolarization activated cyclic nucleotide-gated potassium channel 1" -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- HCN1 (Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 1 (HCN1))
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别名
- HCN1
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背景
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Synonyms: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1,Brain cyclic nucleotide-gated channel 1,BCNG-1,HCN1,BCNG1,
Tissue Specificity: Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. .
Background: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, also known as HAC-2 or BCNG-1, is a protein that in humans is encoded by the HCN1 gene. It is mapped to 5p12. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. It may mediates responses to sour stimuli.
Sequence Similarities: Belongs to the potassium channel HCN family.
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分子量
- 120 kDa
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基因ID
- 348980
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UniProt
- O60741
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途径
- Asymmetric Protein Localization
抗原
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