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Glucagon 抗体 (N-Term)

Name: Glucagon 抗体 (N-Term)
SKU: ABIN3042419
Availability: OutOfStock

This anti-Glucagon antibody is a 兔多克隆 antibody detecting Glucagon in IHC 和 IF. Suitable for 人, 大鼠和小鼠. This Primary Antibody has been cited in 6+ publications.

Anti- GLP1 Picoband antibody, IHC(P) IHC(P): Rat Pancreas Tissue (Glucagon 抗体 (N-Term))

IHC

Anti- GLP1 Picoband antibody, IHC(P) IHC(P): Human Pancreatic Cancer Tissue (Glucagon 抗体 (N-Term))

IHC

Anti- GLP1 Picoband antibody, IHC(P) IHC(P): Mouse Pancreas Tissue (Glucagon 抗体 (N-Term))

IHC

3 images

(6 references)

产品编号 ABIN3042419

发货至: 中国

Quick Overview for Glucagon 抗体 (N-Term) (ABIN3042419)

抗原

See all Glucagon (GCG) 抗体

Glucagon (GCG)

适用

人, 大鼠, 小鼠

宿主

兔

克隆类型

多克隆

标记

This Glucagon antibody is un-conjugated

应用范围

Immunohistochemistry (IHC), Immunofluorescence (IF)

Discover our top product GCG Primary Antibody

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AA 53-81, N-Term

原理

Anti-GLP1/GCG Antibody

序列

HSQGTFTSDY SKYLDSRRAQ DFVQWLMNT

交叉反应（详细）

No cross-reactivity with other proteins

产品特性

Anti-GLP1/GCG Antibody Picoband® (ABIN3042419). Tested in IF, IHC applications. This antibody reacts with Human, Mouse, Rat.

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the N-terminus of human GLP1, identical to the related mouse and rat sequences.

亚型

IgG
anti-Glucagon (GCG) antibody
GCG 适用: 人 WB, IHC, ELISA, IF, FM 宿主: 兔 Polyclonal unconjugated

anti-Glucagon (GCG) (AA 21-180) antibody
GCG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Glucagon (GCG) (AA 119-148), (C-Term) antibody
GCG 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB19525 unconjugated

anti-Glucagon (GCG) antibody
GCG 适用: 人 IHC, IF 宿主: 兔 Monoclonal unconjugated

anti-Glucagon (GCG) antibody
GCG 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Glucagon (GCG) (AA 1-180) antibody
GCG 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1E2-E6 unconjugated

anti-Glucagon (GCG) (AA 53-81) antibody
GCG 适用: 人, 大鼠, 小鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Glucagon (GCG) (AA 23-180) antibody
GCG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Glucagon (GCG) (AA 25-54) antibody
GCG 适用: 人, 小鼠 WB, IHC, IHC (p), FACS 宿主: 兔 Polyclonal unconjugated

anti-Glucagon (GCG) (AA 1-180) antibody
GCG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

应用备注

Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Immunofluorescence, 2 μg/mL, Rat
1. Arora S, Galich P (Mar 2009). "Myth: glucagon is an effective first-line therapy for esophageal foreign body impaction". Cjem 11 (2): 169-71. 2. Holz, G. G., IV, Kuhtreiber, W. M., Habener, J. F. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature 361: 362-365, 1993. 3. Liljenquist JE, Bomboy JD, Lewis SB, Sinclair-Smith BC, Felts PW, Lacy WW, Crofford OB, Liddle GW (Jan 1974). "Effects of glucagon on lipolysis and ketogenesis in normal and diabetic men" (PDF). The Journal of Clinical Investigation 53 (1): 190-7.

说明

Antibody can be supported by ABIN921231 in IHC(P).

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Yang, Yan, Tong, Zhang, Chen, Xue, Wang, Chu, Jin, Li: "Chronic oscillating glucose challenges disarrange innate immune homeostasis to potentiate the variation of neutrophil-lymphocyte ratio in rats with or without hidden diabetes mellitus." in: Diabetes, metabolic syndrome and obesity : targets and therapy, Vol. 11, pp. 277-288, (2018) (PubMed).

Wang, Tian, Chen, Tan, Xie, Chen, Fu, Chen, Xu, Wei: "Low dose doxycycline decreases systemic inflammation and improves glycemic control, lipid profiles, and islet morphology and function in db/db mice." in: Scientific reports, Vol. 7, Issue 1, pp. 14707, (2017) (PubMed).

Zhang, Ye, Wang, Gao, Tan, Zhuo, Liu, Xia, Yang, Li: "Kidney-targeted transplantation of mesenchymal stem cells by ultrasound-targeted microbubble destruction promotes kidney repair in diabetic nephropathy rats." in: BioMed research international, Vol. 2013, pp. 526367, (2013) (PubMed).

Tang, Zhu, Fan, Zhang, Li, Liu, Chen, Zhang, Zhou, Wei: "Intra-arterial targeted islet-specific expression of Sirt1 protects ? cells from streptozotocin-induced apoptosis in mice." in: Molecular therapy : the journal of the American Society of Gene Therapy, Vol. 19, Issue 1, pp. 60-6, (2011) (PubMed).

Lan, Yue, Han, Shi, Yang, Pu, Yao, Kang: "Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer." in: International journal of oncology, Vol. 40, Issue 2, pp. 519-26, (2011) (PubMed).

Chen, Yang, Zheng, Hu, Kong, Zhang: "Effect of catch-up growth after food restriction on the entero-insular axis in rats." in: Nutrition & metabolism, Vol. 7, pp. 45, (2010) (PubMed).
抗原

Glucagon (GCG)

别名

GCG

背景

Synonyms: Glucagon,Glicentin,Glicentin-related polypeptide,GRPP,Oxyntomodulin,OXM,OXY,Glucagon,Glucagon-like peptide 1,GLP-1,Incretin hormone,Glucagon-like peptide 1 (7-37),GLP-1 (7-37),Glucagon-like peptide 1 (7-36),GLP-1 (7-36),Glucagon-like peptide 2,GLP-2,GCG,
Tissue Specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain.
Background: GCG is also known as GLP1, or Glucagon. Glucagon is a 29-amino acid pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis.?It is mapped to 2q36-2q37. GLP1, also known as 7-37 for the codons of the preproglucagon molecule which encode it, renders pancreatic beta-cells 'glucose-competent' and may be useful in the treatment of noninsulin-dependent diabetes mellitus. Also, GLP1 is a potent insulin secretagogue.?It plays a major role in the enteroinsular axis, accounting, for example, for the finding that plasma insulin levels accompanying oral intake of glucose are greater than those observed when glucose is given intravenously.

分子量

10 kDa

基因ID

2641

UniProt

P01275

途径

Positive Regulation of Peptide Hormone Secretion, Peptide Hormone Metabolism, cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour, Negative Regulation of intrinsic apoptotic Signaling