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FOXO1 抗体 (AA 456-655)

Cited in 1 publication. This 兔 多克隆 anti-FOXO1 antibody specifically detects FOXO1 in WB. The antibody is reactive with 人 和 大鼠 samples.
产品编号 ABIN3042403
发货至: 中国
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Quick Overview for FOXO1 抗体 (AA 456-655) (ABIN3042403)

抗原

See all FOXO1 抗体
FOXO1 (Forkhead Box O1 (FOXO1))

适用

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人, 大鼠

宿主

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多克隆

标记

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This FOXO1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
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    AA 456-655

    原理

    Anti-FOXO1A Antibody

    交叉反应 (详细)

    No cross-reactivity with other proteins

    产品特性

    Anti-FOXO1A Antibody (ABIN3042403). Tested in WB applications. This antibody reacts with Human, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

    纯化方法

    Immunogen affinity purified.

    免疫原

    E.coli-derived human FOXO1A recombinant protein (Position: N456-G655). Human FOXO1A shares 93% amino acid (aa) sequence identity with both mouse and rat FOXO1A.

    亚型

    IgG
  • 应用备注

    Western blot, 0.1-0.5 μg/mL, Rat, Human

    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制

    仅限研究用
  • 状态

    Lyophilized

    溶解方式

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    浓度

    500 μg/mL

    缓冲液

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Dong, Mai, Zhang, Mi, Wu, Chu, Yang, Sun: "MiR-15a/b promote adipogenesis in porcine pre-adipocyte via repressing FoxO1." in: Acta biochimica et biophysica Sinica, Vol. 46, Issue 7, pp. 565-71, (2014) (PubMed).

  • 抗原

    FOXO1 (Forkhead Box O1 (FOXO1))

    别名

    FOXO1

    背景

    Synonyms: Forkhead box protein O1,Forkhead box protein O1A,Forkhead in rhabdomyosarcoma,FOXO1,FKHR, FOXO1A,

    Tissue Specificity: Ubiquitous. .

    Background: Forkhead box protein O1, also known as FKHR or FOXO1A, is a protein that in humans is encoded by the FOXO1 gene. It is mapped to 13q14.11. This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXO1 plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. This gene is primarily regulated through phosphorylation on multiple residues. Its transcriptional activity is dependent on its phosphorylation state. What's more, FOXO1 may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma.

    Sequence Similarities: Contains 1 fork-head DNA-binding domain.

    分子量

    70 kDa

    基因ID

    2308

    UniProt

    Q12778

    途径

    PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
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