FOXM1 抗体 (AA 411-763)
Quick Overview for FOXM1 抗体 (AA 411-763) (ABIN3042402)
抗原
See all FOXM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 411-763
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原理
- Anti-FOXM1 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-FOXM1 Antibody Picoband® (ABIN3042402). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human FOXM1 recombinant protein (Position: A411-Q763). Human FOXM1 shares 75% and 76% amino acid (aa) sequences identity with mouse and rat FOXM1, respectively.
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亚型
- IgG
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anti-Forkhead Box M1 (FOXM1) (AA 702-801) antibody
FOXM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 5G10 unconjugated
anti-Forkhead Box M1 (FOXM1) (Middle Region) antibodyFOXM1 适用: 人, 大鼠, 小鼠, 犬, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 209-460) antibodyFOXM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 1-350) antibodyFOXM1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) antibodyKO Validated FOXM1 适用: 人 WB, IP, ChIP, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (C-Term) antibodyKO Validated FOXM1 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 649-748) antibodyFOXM1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 6F11A8 unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 22-110) antibodyFOXM1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2H4 unconjugated
anti-Forkhead Box M1 (FOXM1) (N-Term) antibodyFOXM1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Forkhead Box M1 (FOXM1) (AA 301-400) antibodyFOXM1 适用: 人 ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
1. Ye H, Kelly TF, Samadani U, Lim L, Rubio S, Overdier DG, Roebuck KA, Costa RH (March 1997). "Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues". Mol Cell Biol 17 (3): 1626-41. 2. Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H (March 1998). "The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization". Genomics 46 (3): 435-42. 3. Wierstra I, Alves J (December 2007). "FOXM1, a typical proliferation-associated transcription factor". Biol. Chem. 388 (12): 1257-74. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- FOXM1 (Forkhead Box M1 (FOXM1))
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别名
- FOXM1
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背景
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Synonyms: Forkhead box protein M1,Forkhead-related protein FKHL16,Hepatocyte nuclear factor 3 forkhead homolog 11,HFH-11,HNF-3/fork-head homolog 11,M-phase phosphoprotein 2,MPM-2 reactive phosphoprotein 2,Transcription factor Trident,Winged-helix factor from INS-1 cells,FOXM1,FKHL16, HFH11, MPP2, WIN,
Tissue Specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.
Sequence Similarities: Contains 1 fork-head DNA-binding domain.
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分子量
- 36 kDa
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基因ID
- 2305
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UniProt
- Q08050
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途径
- Positive Regulation of Response to DNA Damage Stimulus
抗原
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