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FOXM1 抗体 (AA 411-763)

FOXM1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN3042402
发货至: 中国
  • 抗原 See all FOXM1 抗体
    FOXM1 (Forkhead Box M1 (FOXM1))
    抗原表位
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 411-763
    适用
    • 46
    • 23
    • 21
    • 3
    • 2
    • 2
    • 1
    • 1
    宿主
    • 35
    • 13
    克隆类型
    • 33
    • 15
    多克隆
    标记
    • 28
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This FOXM1 antibody is un-conjugated
    应用范围
    • 21
    • 20
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB)
    原理
    Anti-FOXM1 Antibody Picoband®
    交叉反应 (详细)
    No cross-reactivity with other proteins
    产品特性
    Anti-FOXM1 Antibody Picoband® (ABIN3042402). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    纯化方法
    Immunogen affinity purified.
    免疫原
    E.coli-derived human FOXM1 recombinant protein (Position: A411-Q763). Human FOXM1 shares 75% and 76% amino acid (aa) sequences identity with mouse and rat FOXM1, respectively.
    亚型
    IgG
    Top Product
    Discover our top product FOXM1 Primary Antibody
  • 应用备注
    Western blot, 0.1-0.5 μg/mL, Human
    1. Ye H, Kelly TF, Samadani U, Lim L, Rubio S, Overdier DG, Roebuck KA, Costa RH (March 1997). "Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues". Mol Cell Biol 17 (3): 1626-41. 2. Korver W, Roose J, Heinen K, Weghuis DO, de Bruijn D, van Kessel AG, Clevers H (March 1998). "The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization". Genomics 46 (3): 435-42. 3. Wierstra I, Alves J (December 2007). "FOXM1, a typical proliferation-associated transcription factor". Biol. Chem. 388 (12): 1257-74.
    说明

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    限制
    仅限研究用
  • 状态
    Lyophilized
    溶解方式
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    浓度
    500 μg/mL
    缓冲液
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • 抗原
    FOXM1 (Forkhead Box M1 (FOXM1))
    别名
    FOXM1 (FOXM1 产品)
    背景

    Synonyms: Forkhead box protein M1,Forkhead-related protein FKHL16,Hepatocyte nuclear factor 3 forkhead homolog 11,HFH-11,HNF-3/fork-head homolog 11,M-phase phosphoprotein 2,MPM-2 reactive phosphoprotein 2,Transcription factor Trident,Winged-helix factor from INS-1 cells,FOXM1,FKHL16, HFH11, MPP2, WIN,

    Tissue Specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.

    Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 "brain washes" normal cells to adopt cancer-like epigenome.

    Sequence Similarities: Contains 1 fork-head DNA-binding domain.

    分子量
    36 kDa
    基因ID
    2305
    UniProt
    Q08050
    途径
    Positive Regulation of Response to DNA Damage Stimulus
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