MEFV 抗体 (N-Term)
Quick Overview for MEFV 抗体 (N-Term) (ABIN3042357)
抗原
See all MEFV 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 5-39, N-Term
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原理
- Anti-MEFV Antibody Picoband®
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序列
- PSDHLLSTLE ELVPYDFEKF KFKLQNTSVQ KEHSR
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交叉反应 （详细）
- No cross-reactivity with other proteins
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产品特性
- Anti-MEFV Antibody Picoband® (ABIN3042357). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- A synthetic peptide corresponding to a sequence at the N-terminus of human MEFV, different from the related mouse sequence by eight amino acids, and from the related rat sequence by eleven amino acids.
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亚型
- IgG
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anti-Mediterranean Fever (MEFV) (AA 1-110) antibody
MEFV 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C1 unconjugated
anti-Mediterranean Fever (MEFV) (AA 1-110) antibodyMEFV 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mediterranean Fever (MEFV) (Internal Region) antibodyVerified MEFV 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Mediterranean Fever (MEFV) (AA 268-374) antibodyMEFV 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mediterranean Fever (MEFV) (N-Term) antibodyMEFV 适用: 人, 小鼠, 犬, Cow, 豚鼠, Bat, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Mediterranean Fever (MEFV) (AA 418-445) antibodyMEFV 适用: 人 WB 宿主: 兔 Polyclonal RB41739 unconjugated
anti-Mediterranean Fever (MEFV) (N-Term) antibodyMEFV 适用: 人, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Dogan H, Akdemir F, Tasdemir S, Atis O, Diyarbakir E, Yildirim R, Emet M, Ikbal M (2014). "A novel insertion mutation identified in exon 10 of the MEFV gene associated with Familial Mediterranean Fever". BMC Medical Genetics 15 (1): 74. 2. Mansfield E, Chae JJ, Komarow HD, Brotz TM, Frucht DM, Aksentijevich I, Kastner DL (Aug 2001). "The familial Mediterranean fever protein, pyrin, associates with microtubules and colocalizes with actin filaments". Blood 98(3): 851-9. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- MEFV (Mediterranean Fever (MEFV))
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别名
- MEFV
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背景
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Synonyms: Pyrin,Marenostrin,MEFV,MEF, TRIM20 ,
Tissue Specificity: Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines. .
Background: MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells (neutrophils, eosinophils and monocytes) that play a role in inflammation and in fighting infection. Inside these white blood cells, pyrin is found with thecytoskeleton, the structural framework that helps to define the shape, size, and movement of a cell. Pyrin's protein structure also allows it to interact with other molecules involved in fighting infection and in the inflammatory response. Although pyrin's function is not fully understood, it likely assists in keeping the inflammation process under control. Research indicates that pyrin helps regulate inflammation by interacting with the cytoskeleton. And Pyrin may the migration of white blood cells to sites of inflammation and stop or slow the inflammatory response when it is no longer needed.
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分子量
- 86 kDa
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基因ID
- 4210
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UniProt
- O15553
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途径
- Positive Regulation of Endopeptidase Activity
抗原
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