BAG3 抗体 (AA 100-561)
Quick Overview for BAG3 抗体 (AA 100-561) (ABIN3042341)
抗原
See all BAG3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 100-561
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原理
- Anti-Bag3 Antibody Picoband®
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交叉反应 （详细）
- No cross-reactivity with other proteins.
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产品特性
- Anti-Bag3 Antibody Picoband® (ABIN3042341). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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纯化方法
- Immunogen affinity purified.
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免疫原
- E.coli-derived human Bag3 recombinant protein (Position: H100-N561). Human Bag3 shares 84.1% amino acid (aa) sequence identity with mouse Bag3.
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亚型
- IgG
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anti-BCL2-Associated Athanogene 3 (BAG3) (C-Term) antibody
Verified BAG3 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 3 (BAG3) antibodyBAG3 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 3 (BAG3) (AA 380-575) antibodyBAG3 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 3 (BAG3) (C-Term) antibodyBAG3 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 3 (BAG3) (AA 220-420) antibodyBAG3 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 3 (BAG3) antibodyBAG3 适用: 人 WB, ELISA, IHC 宿主: 兔 Monoclonal 3D8 unconjugated Recombinant Antibody
anti-BCL2-Associated Athanogene 3 (BAG3) (AA 1-575) antibodyBAG3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 3 (BAG3) (AA 1-575) antibodyBAG3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5A8 unconjugated
anti-BCL2-Associated Athanogene 3 (BAG3) (AA 2-577) antibodyBAG3 适用: 小鼠 ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-BCL2-Associated Athanogene 3 (BAG3) (AA 31-62) antibodyBAG3 适用: 人 WB 宿主: 兔 Polyclonal RB54138 unconjugated
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应用备注
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Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
1. Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J (January 2010). "Chaperone-assisted selective autophagy is essential for muscle maintenance". Curr Biol 20 (2): 143-8. 2. Homma, S., Iwasaki, M., Shelton, G. D., Engvall, E., Reed, J. C., Takayama, S. BAG3 deficiency results in fulminant myopathy and early lethality. Am. J. Path. 169: 761-773, 2006. 3. Villard, E, Perret, C, Gary, F, Proust, C, Dilanian, G, Hengstenberg, C, Ruppert, V, Arbustini, E, Wichter, T, Germain, M, Dubourg, O, Tavazzi, L, Aumont, MC, DeGroote, P, Fauchier, L, Trochu, JN, Gibelin, P, Aupetit, JF, Stark, K, Erdmann, J, Hetzer, R, Roberts, AM, Barton, PJ, Regitz-Zagrosek, V, Cardiogenics Consortium, Aslam, U, Duboscq-Bidot, L, Meyborg, M, Maisch, B, Madeira, H, Waldenström, A, Galve, E, Cleland, JG, Dorent, R, Roizes, G, Zeller, T, Blankenberg, S, Goodall, AH, Cook, S, Tregouet, DA, Tiret, L, Isnard, R, Komajda, M, Charron, P, Cambien, F (April 1, 2011). A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy 32 (9). pp. 1065-76. -
说明
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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浓度
- 500 μg/mL
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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- BAG3 (BCL2-Associated Athanogene 3 (BAG3))
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别名
- BAG3
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背景
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Synonyms: BAG family molecular chaperone regulator 3,BAG-3,Bcl-2-associated athanogene 3,Bcl-2-binding protein Bis,Docking protein CAIR-1,BAG3,BIS,
Tissue Specificity: Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart. .
Background: BAG family molecular chaperone regulator 3 (BAG3) is a member of a conserved family of cyto-protective proteins that bind to and regulate Hsp70 family molecular chaperones. BAG3 mutations are responsible for familial dilated cardiomyopathy. BAG3 polymorphisms are also associated with sporadic forms of the disease together with HSPB7 locus. In muscle cells, BAG3 cooperates with the molecular chaperones Hsc70 and HspB8 to induce the degradation of mechanically damaged cytoskeleton components in lysosomes. This process is called chaperone-assisted selective autophagy (CASA) and is essential for maintaining muscle activity in flies, mice and men.
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分子量
- 80 kDa
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基因ID
- 9531
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UniProt
- O95817
抗原
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