RIP2 抗体 (C-Term)
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Quick Overview for RIP2 抗体 (C-Term) (ABIN3032495)
抗原
See all RIP2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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纯化方法
- Antigen affinity
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免疫原
- An amino acid sequence from the C-terminus of human RIP2 (DIQGEEFAKVIVQKLKDNKQ) was used as the immunogen for this RIP2 antibody.
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亚型
- IgG
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anti-ROP Interactive Partner 2 (RIP2) (AA 401-540) antibody
RIP2 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-ROP Interactive Partner 2 (RIP2) (Tyr397) antibodyRIP2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ROP Interactive Partner 2 (RIP2) (pSer176) antibodyRIP2 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-ROP Interactive Partner 2 (RIP2) (Ser176) antibodyRIP2 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the RIP2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the RIP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- RIP2 (ROP Interactive Partner 2 (RIP2))
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别名
- RIP2
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背景
- Receptor-interacting serine/threonine-protein kinase 2, also known as CARD3, CARDIAK, RICK, and RIP2, is an enzyme that in humans is encoded by the RIPK2 gene. It has 540-amino acid protein in length. Northern blot analysis revealed that RIPK2 is expressed in various human tissues as 2.5- and 1.8-kb mRNAs that differ due to alternative polyadenylation. It is a novel kinase that may regulate apoptosis induced by the FAS receptor pathway. This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminalcaspase recruitment domain(CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappa Band inducer of apoptosis in response to various stimuli, CARDIAK (CARD-containing ICE-associated kinase) specifically interacted with the CARD of ICE/caspase-1, and this interaction correlated with the processing of pro-caspase-1 and the formation of the active caspase-1 p20 subunit.
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UniProt
- O43353
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途径
- TCR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades
抗原
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