PTTG1 抗体 (AA 146-161)
Quick Overview for PTTG1 抗体 (AA 146-161) (ABIN3032234)
抗原
See all PTTG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 146-161
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纯化方法
- Antigen affinity
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免疫原
- Amino acids 146-161 (LMILDEERELEKLFQL-human) were used as the immunogen for this Securin antibody.
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亚型
- IgG
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anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 2-199) antibody
PTTG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (Internal Region) antibodyVerified PTTG1 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-202) antibodyPTTG1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 2-202) antibodyPTTG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 16-45), (N-Term) antibodyPTTG1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB18596 unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 93-113) antibodyPTTG1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 1G10 unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 101-202) antibodyPTTG1 适用: 人, 小鼠, 大鼠 ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 2-202) antibodyPTTG1 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-100) antibodyPTTG1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-100) antibodyPTTG1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1D9 unconjugated
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the Securin antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the Securin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
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别名
- Securin
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背景
- Securin, also known as pituitary tumor-transforming 1 or EAP1 is a protein that in humans is encoded by the PTTG1 gene. The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex(APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and is highly expressed in various tumors. Securin contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box(D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. It is mainly a cytosolic protein, although it partially localizes in the nucleus.
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UniProt
- O95997
抗原
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