MTDH 抗体 (AA 101-270)
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北京 101111
Quick Overview for MTDH 抗体 (AA 101-270) (ABIN3031760)
抗原
See all MTDH 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 101-270
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纯化方法
- Antigen affinity
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免疫原
- Human partial recombinant protein (AA 101-270) was used as the immunogen for this LYRIC antibody.
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亚型
- IgG
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the LYRIC antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,ICC: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the LYRIC antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- MTDH (Metadherin (MTDH))
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别名
- LYRIC (Metadherin)
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背景
- MTDH (Metadherin), also known as LYRIC or astrocyte elevated gene-1 protein (AEG-1), is a protein that in humans is encoded by the MTDH gene. It is involved in < a href=../search_result.php?search_txt=hif-1 alpha>HIF-1 alpha mediated angiogenesis, interacts with SND1 and is involved in RNA-induced silencing complex (RISC), and plays a very important role in RISC and miRNA functions. LYRIC induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (< a href=../search_result.php?search_txt=mmp9>MMP9). LYRIC acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.
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基因ID
- 92140
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途径
- Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
抗原
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