ITGAL 抗体 (AA 404-769)
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Quick Overview for ITGAL 抗体 (AA 404-769) (ABIN3031369)
抗原
See all ITGAL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 404-769
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纯化方法
- Antigen affinity
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免疫原
- Human partial recombinant protein (AA 404-769) was used as the immunogen for this LFA-1 antibody.
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亚型
- IgG
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the LFA-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL,IF/ICC: 1-2 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the LFA-1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- ITGAL (Integrin alpha-L (ITGAL))
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别名
- LFA-1
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背景
- Lymphocyte function associated antigen 1, also known as CD18, is a protein that in humans is encoded by the ITGB2 gene. It is an integrin protein that belongs to the class of cell membrane glycoproteins. The beta-2 integrin chain gene is designated ITGB2 and the leukocyte antigen has been designated LFA-1/CD18. The expression of LFA-1 is increased in lymphoblastoid cells from persons with Down syndrome, consistent with the location of the gene on chromosome 21. In humans lack of LFA-1 causes Leukocyte Adhesion Deficiency, a disease defined by a lack of leukocyte extravasation from blood into tissues. Although the protein is expressed on the cell surface at normal levels and is capable of function following extracellular stimulation, it could not be activated via the 'inside-out' signaling pathways.
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基因ID
- 3689
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途径
- Activated T Cell Proliferation, Integrin Complex
抗原
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