HAVCR1 抗体 (AA 289-307)
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北京 101111
Quick Overview for HAVCR1 抗体 (AA 289-307) (ABIN3031182)
抗原
See all HAVCR1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 289-307
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原理
- TIM-1 Antibody / KIM-1
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纯化方法
- Antigen affinity
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免疫原
- Amino acids 289-307 (HPRAEDNIYIIEDRSRGAE-rat) were used as the immunogen for this TIM-1 antibody.
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亚型
- IgG
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anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (C-Term) antibody
HAVCR1 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 21-240) antibodyHAVCR1 适用: 人 WB 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 70-290) antibodyHAVCR1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3A12E10 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 70-290) antibodyHAVCR1 适用: 人, 小鼠 WB, ELISA 宿主: 小鼠 Monoclonal 3D9F5 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 22-235) antibodyHAVCR1 适用: 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 1-364) antibodyHAVCR1 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2G11 unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 21-240) antibodyHAVCR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) antibody (PE)HAVCR1 适用: 小鼠 FACS 宿主: 大鼠 Monoclonal RMT1-10 PE
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) antibodyHAVCR1 适用: 小鼠 IHC, FACS, IF, Agon 宿主: 兔 Chimeric 3B3 unconjugated Recombinant Antibody
anti-Hepatitis A Virus Cellular Receptor 1 (HAVCR1) (AA 22-235) antibodyHAVCR1 适用: 大鼠 IHC 宿主: 小鼠 Monoclonal C8 unconjugated
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应用备注
- Titration of the TIM-1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- 4 °C,-20 °C
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储存方法
- The lyophilized TIM-1 antibody can be stored at 4oC to -20oC. After reconstitution, aliquot and store at -20oC. Avoid repeated freezing and thawing.
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- HAVCR1 (Hepatitis A Virus Cellular Receptor 1 (HAVCR1))
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别名
- TIM-1
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物质类
- Virus
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背景
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TIM-1 antibody targets T cell immunoglobulin and mucin domain containing protein 1, also widely known as Kidney injury molecule 1 (KIM-1) and encoded by the HAVCR1 gene. TIM-1 is a type I transmembrane glycoprotein with an extracellular immunoglobulin V-like domain and a mucin-rich region, localized primarily to the plasma membrane. Under normal physiological conditions, TIM-1 expression in kidney tissue is low, but it is strongly induced in proximal tubular epithelial cells following renal injury, making it a well-established marker of kidney damage.
Functionally, T cell immunoglobulin and mucin domain containing protein 1 participates in epithelial cell injury responses, phagocytosis of apoptotic debris, and immune modulation. TIM-1 has been shown to act as a scavenger receptor that recognizes phosphatidylserine on apoptotic cells, facilitating clearance and tissue repair processes. In immune cells, TIM-1 can influence T cell activation and cytokine production, linking tissue injury signals with immune regulation. A TIM-1 antibody supports studies focused on renal injury mechanisms and immune signaling.
TIM-1 expression is most prominently associated with injured kidney epithelium, but it is also detected in activated immune cells, including subsets of T lymphocytes. Its inducible expression pattern reflects a role in sensing cellular stress and damage rather than maintaining baseline tissue function. TIM-1 can interact with multiple ligands and signaling partners, enabling it to participate in pathways that regulate inflammation, tissue remodeling, and immune responses following injury.
From a disease-relevance perspective, TIM-1, also referred to as KIM-1, is extensively studied as a biomarker for acute kidney injury and chronic kidney disease. Elevated TIM-1 expression correlates with tubular damage and disease severity, and it has been investigated in toxicological studies, ischemia-reperfusion injury, and drug-induced nephrotoxicity. Beyond renal disease, TIM-1 has also been explored in inflammatory disorders and cancer biology, where its immune regulatory functions may contribute to disease progression.
At the molecular level, T cell immunoglobulin and mucin domain containing protein 1 contains conserved structural domains that support ligand binding and signal transduction. Glycosylation of the mucin domain can influence apparent migration behavior on SDS-PAGE without implying changes in primary sequence. TIM-1 antibody reagents support research applications focused on kidney injury, epithelial stress responses, and immune regulation, with NSJ Bioreagents providing reagents intended for research use. -
UniProt
- O54947
抗原
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