Cullin 4B 抗体 (C-Term)
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- 抗原 See all Cullin 4B (CUL4B) 抗体
- Cullin 4B (CUL4B)
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠, 斑马鱼
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Cullin 4B antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- Antigen affinity
- 免疫原
- An amino acid sequence from the C-terminus of human Cullin 4B (DRDYMERDKENPNQYNYIA) was used as the immunogen for this Cullin 4B antibody (100% homologous in human, mouse and rat).
- 亚型
- IgG
- Top Product
- Discover our top product CUL4B Primary Antibody
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anti-Cullin 4B (CUL4B) (Internal Region) antibody
CUL4B 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (AA 1-300) antibodyCUL4B 适用: 人, 小鼠, 犬 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 1C4 unconjugated
anti-Cullin 4B (CUL4B) (AA 1-200) antibodyCUL4B 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (AA 9-152) antibodyCUL4B 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (AA 1-913) antibodyCUL4B 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) antibodyCUL4B 适用: 人, 大鼠, 斑马鱼 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) antibodyCUL4B 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) antibodyCUL4B 适用: 人, 大鼠, 斑马鱼, 鱼 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4B (CUL4B) (AA 1-300) antibodyCUL4B 适用: 人, 小鼠, 大鼠, 犬, 猴 WB 宿主: 小鼠 Monoclonal 7F8 unconjugated
anti-Cullin 4B (CUL4B) (AA 250-278) antibodyCUL4B 适用: 人 WB 宿主: 兔 Polyclonal RB42521 unconjugated
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- 应用备注
- The stated application concentrations are suggested starting amounts. Titration of the Cullin 4B antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
- 限制
- 仅限研究用
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- 缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
- 储存条件
- -20 °C
- 储存方法
- After reconstitution, the Cullin 4B antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- 抗原
- Cullin 4B (CUL4B)
- 别名
- Cullin 4B (CUL4B 产品)
- 别名
- MRXHF2 antibody, MRXS15 antibody, MRXSC antibody, SFM2 antibody, 2700050M05Rik antibody, AA409770 antibody, CUL-4B antibody, mKIAA0695 antibody, RGD1564494 antibody, im:7140950 antibody, im:7150765 antibody, MGC115611 antibody, Tb03.1J15.620 antibody, sfm2 antibody, mrxsc antibody, mrxhf2 antibody, cullin 4B antibody, cullin 4B S homeolog antibody, CUL4B antibody, Cul4b antibody, cul4b antibody, cul4b.S antibody, Tb927.3.1290 antibody
- 背景
- Cullin 4B/CUL4B encodes a scaffold protein that organizes a cullin-RING(really interesting new gene) ubiquitin ligase(E3) complex in ubiquitylation. The CUL4 gene encodes a protein of 913 amino acids. The cullin domain is located between amino acid residues 217 and 815 and is characterized a by C-terminal globular domain(cullin homology domain) and a series of N-terminal repeats(cullin repeats). Ohtake et al.(2007) characterize a fat-soluble ligand-dependent ubiquitin ligase complex in human cell lines, in which dioxin receptor(AhR) is integrated as a component of a novel cullin 4B ubiquitin ligase complex, CUL4B(AhR). Complex assembly and ubiquitin ligase activity of CUL4B(AhR) in vitro and in vivo are dependent on the AhR ligand. In the CUL4B(AhR) complex, ligand-activated AhR acts as a substrate-specific adaptor component that targets sex steroid receptors for degradation. Their findings uncover a function for AhR as an atypical component of the ubiquitin ligase complex and demonstrate a non-genomic signalling pathway in which fat-soluble ligands regulate target-protein-selective degradation through a ubiquitin ligase complex.
- UniProt
- Q13620
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