CCR10 抗体 (AA 312-327)
Quick Overview for CCR10 抗体 (AA 312-327) (ABIN3030490)
抗原
See all CCR10 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 312-327
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纯化方法
- Antigen affinity
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免疫原
- Amino acids 312-327 (FLGLRFRQDLRRLLRG-human) were used as the immunogen for this CCR10 antibody.
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亚型
- IgG
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anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (AA 1-52) antibody
CCR10 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (C-Term) antibodyCCR10 适用: 人, 小鼠, 大鼠, 犬, Pig, Bat, Cow, 猴 ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (Extracellular Domain) antibodyCCR10 适用: 人, 犬, Pig, Bat IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (C-Term) antibodyCCR10 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (AA 9-31) antibodyCCR10 适用: 人 WB, ELISA, IHC, FACS, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Chemokine (C-C Motif) Receptor 10 (CCR10) (AA 1-30) antibodyCCR10 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the CCR10 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the CCR10 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- CCR10 (Chemokine (C-C Motif) Receptor 10 (CCR10))
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别名
- CCR10
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背景
- C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. It is constitutively expressed in skin melanocytes, fibroblasts, and microvascular endothelial cells, and that it is upregulated by IL1B and TNF. Expression was also detected in T cells, Langerhans cells, and peripheral blood mononuclear cells but not in dendritic cells. By fluorescence in situ hybridization, the gene is mapped to 17q21.1-q21.3. CCR10 is the receptor for CCL27. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation. expression of CCL27 in normal keratinocytes and its strong upregulation in skin lesions of atopic dermatitis, contact dermatitis, and psoriasis patients. CCR10+ T lymphocytes were detected in lesional but not normal skin of these patients. Flow cytometric analysis showed that CCL27 binds extracellular matrix components and dermal microvascular endothelial cells and fibroblasts and mediates adhesion and transendothelial migration of CCR10+ circulating leukocytes. The protein is predominantly expressed on CD4+CLA+(cutaneous lymphocyte antigen), rather than CD8+, circulating T cells. RT-PCR, confocal microscopy, and ELISA analysis indicated that keratinocytes exposed to TNF or IL1B but not to IL4 or IFNG in vitro express increased CCL27.
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UniProt
- P46092
抗原
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