CASP14 抗体 (AA 223-242)
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Quick Overview for CASP14 抗体 (AA 223-242) (ABIN3030293)
抗原
See all CASP14 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 223-242
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纯化方法
- Antigen affinity
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免疫原
- Amino acids 223-242 (KARKTNPEIQSTLRKRLYLQ-human) were used as the immunogen for this Caspase-14 antibody.
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亚型
- IgG
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应用备注
- The stated application concentrations are suggested starting points. Titration of the Caspase-14 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the Caspase-14 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
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别名
- Caspase-14
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背景
- Caspase 14 is an enzyme that in humans is encoded by the CASP14 gene. CASP14 belongs the evolutionarily conserved caspase family. CASP14 was assigned to chromosome 19p13.1. Using Northern blot and semiquantitative RT-PCR analyses, it was showed that CASP14 was transcriptionally upregulated during maintenance of confluent cultures of human epidermal keratinocytes. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. Caspase 14 seems to play a role in keratinocyte differentiation and cornification and probably regulates maturation of the epidermis by proteolytically processing filaggrin.
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UniProt
- P31944
抗原
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