IDO 抗体 (N-Term)
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Quick Overview for IDO 抗体 (N-Term) (ABIN3029730)
抗原
See all IDO 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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纯化方法
- Antigen affinity
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免疫原
- An amino acid sequence from the N-terminus of human Indoleamine 2, 3-dioxygenase (MAHAMENSWTISKEYHIDEE) was used as the immunogen for this IDO antibody.
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亚型
- IgG
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anti-Indoleamine 2,3-Dioxygenase (IDO) (AA 2-403) antibody
IDO 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase (IDO) (AA 2-403) antibodyIDO 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C13 unconjugated
anti-Indoleamine 2,3-Dioxygenase (IDO) (AA 106-190) antibodyIDO 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase (IDO) (AA 276-360) antibodyIDO 适用: 大鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Indoleamine 2,3-Dioxygenase (IDO) (AA 26-199) antibodyIDO 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- The stated application concentrations are suggested starting amounts. Titration of the IDO antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL
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限制
- 仅限研究用
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缓冲液
- 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
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储存条件
- -20 °C
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储存方法
- After reconstitution, the IDO antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
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- IDO (Indoleamine 2,3-Dioxygenase (IDO))
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别名
- IDO Indoleamine 2, 3-Dioxygenase
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背景
- Indoleamine 2,3-dioxygenase, also called INDO or IDO, is an immunomodulatory enzyme produced by some alternatively activated macrophages and other immunoregulatory cells. This enzyme catalyzes the degradation of the essential amino acid L-tryptophan to N-formyl-kynurenine. By fluorescence in situ hybridization, the assignment is narrowed to chromosome 8p12-p11. IDO-Interferon-gamma interaction has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as Toxoplasma and chlamydia, at least partly because of the induction of indoleamine 2,3-dioxygenase. During inflammation, IDO is upregulated in dendritic cells and phagocytes by proinflammatory stimuli, most notably IFNG, and the enzyme then uses superoxide as a 'cofactor' for oxidative cleavage of the indole ring of tryptophan, yielding an intermediate that deformylates to L-kynurenine.
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UniProt
- P14902
抗原
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