Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
特异性
This antibody reacts to a synthetic peptide corresponding to amino acids near the carboxy terminus of human PERP, which differ from the mouse sequence by three amino acids (7-9).
Western Blot: 0,5 - 1 μg/mL. Immunohistochemistry: 5 μg/mL. Immunocytochemistry. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.Synonyms: KCP-1, KCP1, KRTCAP1, Keratinocyte-associated protein 1, P53-induced protein PIGPC1, PERP, PIGPC1, THW, Transmembrane protein THW, p53 apoptosis effector related to PMP-22