ABO, Blood Group A Antigen 抗体
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Quick Overview for ABO, Blood Group A Antigen 抗体 (ABIN3026867)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Blood Group Antigen A Antibody / ABO
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产品特性
- This mAb preferably reacts with determinants of chain A and H type 3 (Gal1-3GalNAc-R) and 4 (Gal1-3GalNAc-R), but not with type 1 and 2 chain structures. It is not reactive with immuno-dominant A trisaccharide. This mAb is applicable for tissue staining in tumor patients with blood groups A and AB. It shows a highly heterogeneous reactivity in human colon tumor tissue and adjacent mucosa. Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. The A, B and H antigens are reported to undergo modulation during malignant cellular transformation. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens.
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纯化方法
- Protein G affinity chromatography
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免疫原
- Mucin isolated from an ovarian cyst fluid was used as the immunogen for the Blood Group Antigen A antibody.
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亚型
- IgG1, kappa
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anti-ABO, Blood Group A Antigen antibody
适用: 人 IHC (p), AGG 宿主: 小鼠 Monoclonal HE-193 unconjugated
anti-ABO, Blood Group A Antigen antibody适用: 人 FACS 宿主: 小鼠 Monoclonal HE-195 unconjugated
anti-ABO, Blood Group A Antigen antibody (PE)适用: 人 FACS 宿主: 小鼠 Monoclonal HE-193 PE
anti-ABO, Blood Group A Antigen antibody适用: 人 AGG 宿主: 小鼠 Monoclonal HE-195 unconjugated
anti-ABO, Blood Group A Antigen antibody适用: 人 IHC (p), AGG 宿主: 小鼠 Monoclonal HE-193 unconjugated
anti-ABO, Blood Group A Antigen antibodyCarrier-free 适用: 人 IHC (p) 宿主: 小鼠 Monoclonal 33C13 unconjugated
anti-ABO, Blood Group A Antigen antibody适用: 人 IHC, IF 宿主: 小鼠 Monoclonal HE-193 unconjugated
anti-ABO, Blood Group A Antigen antibodyCarrier-free 适用: 人 IHC, IF 宿主: 小鼠 Monoclonal HE-193 unconjugated
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应用备注
- Optimal dilution of the Blood Group Antigen A antibody should be determined by the researcher.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store the Blood Group Antigen A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
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- ABO, Blood Group A Antigen
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别名
- Blood Group Antigen A
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背景
- This mAb preferably reacts with determinants of chain A and H type 3 (Gal1-3GalNAc-R) and 4 (Gal1-3GalNAc-R), but not with type 1 and 2 chain structures. It is not reactive with immuno-dominant A trisaccharide. This mAb is applicable for tissue staining in tumor patients with blood groups A and AB. It shows a highly heterogeneous reactivity in human colon tumor tissue and adjacent mucosa. Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. The A, B and H antigens are reported to undergo modulation during malignant cellular transformation. Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. They are usually mucin-type, and are detected on erythrocytes, certain epithelial cells, and in secretions of certain individuals. Sixteen genetically and biosynthetically distinct but inter-related specificities belong to this group of antigens, including A, B, H, Lewis A, Lewis B, Lewis X, Lewis Y, and precursor type 1 chain antigens.
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UniProt
- P16442
抗原
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