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GNRHR 抗体 (AA 1-29)

GNRHR 适用: 人, 大鼠, 兔 IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal F1G4 or GNRH03 unconjugated
产品编号 ABIN3026047
发货至: 中国
  • 抗原 See all GNRHR 抗体
    GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))
    抗原表位
    • 29
    • 25
    • 8
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-29
    适用
    • 61
    • 14
    • 13
    • 1
    • 1
    人, 大鼠, 兔
    宿主
    • 35
    • 27
    • 1
    小鼠
    克隆类型
    • 35
    • 28
    单克隆
    标记
    • 32
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GNRHR antibody is un-conjugated
    应用范围
    • 28
    • 27
    • 25
    • 24
    • 9
    • 8
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    Protein G affinity chromatography
    免疫原
    A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRHR was used as the immunogen for the GnRH Receptor antibody.
    克隆位点
    F1G4 or GNRH03
    亚型
    IgG1 kappa
    Top Product
    Discover our top product GNRHR Primary Antibody
  • 应用备注
    Optimal dilution of the GnRH Receptor antibody should be determined by the researcher.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10  mM Tris with 1  mM EDTA,  pH 9.0, for 10-20 min followed by cooling at RT for 20 min
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 1-2 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL for 30 min at RT (1),Prediluted format : incubate for 30 min at RT (2)

    限制
    仅限研究用
  • 浓度
    0.2 mg/mL
    缓冲液
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store the GnRH Receptor antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • 抗原
    GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))
    别名
    GnRH Receptor (GNRHR 产品)
    别名
    GNRHR1 antibody, GRHR antibody, HH7 antibody, LHRHR antibody, LRHR antibody, GNRHR antibody, GH1 antibody, Lhrhr antibody, GNRHR1/III antibody, GNRHR2 antibody, xgnrhr antibody, gnrhr3/ii antibody, gnrh-r antibody, gonadotropin releasing hormone receptor antibody, gonadotropin-releasing hormone receptor antibody, GNRHR antibody, Gnrhr antibody, gnrhr antibody, gnrh-r antibody
    背景
    Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.
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