PDE9A 抗体
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北京 101111
Quick Overview for PDE9A 抗体 (ABIN302526)
抗原
See all PDE9A 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- This antibody detects Phosphodiesterase 9A (PDE9A) at internal domain.
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纯化方法
- Immunoaffinity chromatography
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免疫原
- PDE9A antibody was raised against synthetic peptide from human PDE9A.
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应用备注
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Immunohistochemistry on paraffin sections (20 μg/mL). Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1xTBS with Tween (TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- PBS containing 0.09 % sodium azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.
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- PDE9A (phosphodiesterase 9A (PDE9A))
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别名
- PDE9A
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背景
- Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003). PDE9A has been implicated in penile erectile dysfunction, as well as in functional disturbances in which intraneuronal signal transmission via second messengers are important in the pathophysiology (example, bipolar affective disorder). PDE9A is the only cGMP-specific PDE with significant expression in the forebrain, and as such is likely to function in NO-cGMP signaling.Synonyms: 5'-cyclic phosphodiesterase 9A, HSPDE9A2, High affinity cGMP-specific 3', Phosphodiesterase 9A, Phosphodiesterase PDE9A21
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基因ID
- 5152
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NCBI登录号
- NP_001001567
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UniProt
- O76083
抗原
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