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PTH 抗体 (AA 32-115)

PTH 适用: 人 IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal PTH-1173 unconjugated
产品编号 ABIN3024771
发货至: 中国
  • 抗原 See all PTH 抗体
    PTH (Parathyroid Hormone (PTH))
    抗原表位
    • 32
    • 26
    • 19
    • 14
    • 10
    • 9
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 32-115
    适用
    • 162
    • 9
    • 9
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    宿主
    • 102
    • 70
    • 15
    • 2
    小鼠
    克隆类型
    • 101
    • 86
    单克隆
    标记
    • 119
    • 20
    • 13
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTH antibody is un-conjugated
    应用范围
    • 68
    • 63
    • 57
    • 48
    • 41
    • 27
    • 22
    • 16
    • 14
    • 10
    • 8
    • 8
    • 6
    • 5
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    产品特性
    Epitope of this mAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
    纯化方法
    Protein G affinity chromatography
    免疫原
    Amino acids 32-115 of human PTH was used as the immunogen for the Parathyroid Hormone antibody.
    克隆位点
    PTH-1173
    亚型
    IgG2b kappa
    Top Product
    Discover our top product PTH Primary Antibody
  • 应用备注
    Optimal dilution of the Parathyroid Hormone antibody should be determined by the researcher.

    1. Staining of formalin-fixed tissues requires boiling tissue sections in 10  mM Citrate buffer,  pH 6.0, for 10-20 min followed by cooling at RT for 20 min.
    2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. Flow Cytometry: 0.5-1 μg/million cells in 0.1ml,Immunofluorescence: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 0.5-1 μg/mL for 30 min at RT (1),Prediluted format: incubate for 30 min at RT (2)

    限制
    仅限研究用
  • 浓度
    0.2 mg/mL
    缓冲液
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store the Parathyroid Hormone antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • 抗原
    PTH (Parathyroid Hormone (PTH))
    别名
    Parathyroid Hormone (PTH 产品)
    别名
    PTH1 antibody, Pthp antibody, PTH-(1-84) antibody, Pth1 antibody, Pthr1 antibody, PTH antibody, parathyroid hormone antibody, parathyroid hormone S homeolog antibody, PTH antibody, Pth antibody, pth.S antibody
    物质类
    Hormone
    背景
    Epitope of this mAb maps in the C-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion. It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
    途径
    cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process
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